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Open AccessEfficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9
Phenotypic selection during animal domestication has resulted in unwanted incorporation of deleterious mutations. In horses, the autosomal recessive condition known as Glycogen Branching Enzyme Deficiency (GBE...
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Open AccessGenetic engineering a large animal model of human hypophosphatasia in sheep
The availability of tools to accurately replicate the clinical phenotype of rare human diseases is a key step toward improved understanding of disease progression and the development of more effective therapeu...
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Open AccessGenome edited sheep and cattle
Genome editing tools enable efficient and accurate genome manipulation. An enhanced ability to modify the genomes of livestock species could be utilized to improve disease resistance, productivity or breeding ...
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