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Open AccessAuthor Correction: The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption
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Open AccessA new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy
Prostate cancer (PCa) is the most common malignancy diagnosed in men. Immune checkpoint blockade (ICB) alone showed disappointing results in PCa. It is partly due to the formation of immunosuppressive tumor mi...
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Open AccessThe endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption
Chronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heighten...
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Article
Open AccessBayesian phylodynamic analysis reveals the evolutionary history and the dispersal patterns of citrus tristeza virus in China based on the p25 gene
Citrus tristeza virus (CTV) is one of the most serious threats to the citrus industry, and is present in both wild and cultivated citrus. The origin and dispersal patterns of CTV is still poorly understood in ...
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Population genetic characteristics of citrus tristeza virus from wild mandarins in the Nanling Mountains of China
Citrus tristeza virus (CTV) is a viral pathogen that affects the citrus industry worldwide. Knowledge of the genetic structure and evolution of CTV, particularly in CTV from wild mandarins, is limited but esse...
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Open AccessAuthor Correction: [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease
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Open Access[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the brain accumulation of amyloid-β and tau proteins. A growing body of literature suggests that epigenetic dysregulations play a role in the interplay of hallmark ...
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Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer
Castration-resistant prostate cancer (CRPC) is the most common cause of death in men. The effectiveness of HDAC inhibitors has been demonstrated by preclinical models, but not in clinical studies, probably due...
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Radiosynthesis of [11C]EI1 for imaging EZH2 using positron emission tomography
Enhancer of zeste homolog 2 (EZH2) is responsible for the methylation of lysine 27 of histone H3 (H3K27) leading to transcriptional repression. Consequently, EZH2 is related with several diseases including can...
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Open AccessIn vivo human brain expression of histone deacetylases in bipolar disorder
The etiology of bipolar disorder (BD) is unknown and the neurobiological underpinnings are not fully understood. Both genetic and environmental factors contribute to the risk of BD, which may be linked through...
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Article
Synthesis of a carbon-11 radiolabeled BACE1 inhibitor
Beta-secretase (BACE1), a transmembrane aspartyl protease, can cleave membrane-bound β-amyloid precursor proteins (APPs) to initiate the accumulation of amyloid-β (Aβ). The inhibition of BACE-1 to limit the ac...
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Open AccessNeuroepigenetic signatures of age and sex in the living human brain
Age- and sex-related alterations in gene transcription have been demonstrated, however the underlying mechanisms are unresolved. Neuroepigenetic pathways regulate gene transcription in the brain. Here, we meas...
