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  1. Article

    Open Access

    A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy

    Prostate cancer (PCa) is the most common malignancy diagnosed in men. Immune checkpoint blockade (ICB) alone showed disappointing results in PCa. It is partly due to the formation of immunosuppressive tumor mi...

    Zude Chen, **aoshuang Yang, Zugen Chen, Minzhao Li, Wei Wang, Riwei Yang… in BMC Medicine (2023)

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  2. No Access

    Article

    Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer

    Castration-resistant prostate cancer (CRPC) is the most common cause of death in men. The effectiveness of HDAC inhibitors has been demonstrated by preclinical models, but not in clinical studies, probably due...

    Zude Chen, **ashuang Wang, **aoshuang Yang… in European Journal of Nuclear Medicine and M… (2021)

  3. No Access

    Article

    Radiosynthesis of [11C]EI1 for imaging EZH2 using positron emission tomography

    Enhancer of zeste homolog 2 (EZH2) is responsible for the methylation of lysine 27 of histone H3 (H3K27) leading to transcriptional repression. Consequently, EZH2 is related with several diseases including can...

    Hao Wang, Yu Lan, ** Bai, Zude Chen, Shenglin Luo… in Medicinal Chemistry Research (2020)