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  1. Article

    Open Access

    A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth

    Preterm birth (PTB), defined as delivery before 37 gestational weeks, imposes significant public health burdens. A recent maternal genome-wide association study of spontaneous PTB identified a noncoding locus ...

    Li Wang, Robert M. Rossi, **aoting Chen, **g Chen, Jilian Runyon… in BMC Medicine (2023)

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  2. Article

    Open Access

    A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth

    Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin interaction maps are compared to ide...

    Chong Wang, **ang Liu, Jun Liang, Yohei Narita, Weiyue Ding… in Nature Communications (2023)

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  3. Article

    Open Access

    Global discovery of lupus genetic risk variant allelic enhancer activity

    Genome-wide association studies of Systemic Lupus Erythematosus (SLE) nominate 3073 genetic variants at 91 risk loci. To systematically screen these variants for allelic transcriptional enhancer activity, we c...

    **aoming Lu, **aoting Chen, Carmy Forney, Omer Donmez… in Nature Communications (2021)

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  4. No Access

    Article

    Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

    Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. Using new computational methods, we show that transcription factors ...

    John B. Harley, **aoting Chen, Mario Pujato, Daniel Miller, Avery Maddox… in Nature Genetics (2018)