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Article
Open AccessA DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth
Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin interaction maps are compared to ide...
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Article
Open AccessPrimary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
Primary effusion lymphoma (PEL) has a very poor prognosis. To evaluate the contributions of enhancers/promoters interactions to PEL cell growth and survival, here we produce H3K27ac HiChIP datasets in PEL cell...
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Article
Publisher Correction: Defective Epstein–Barr virus in chronic active infection and haematological malignancy
In the version of this Letter originally published, in the sentence beginning “The major driver role of DDX3X mutations...”, the citation “Fig. 2a–f” should have been “Fig. 2”. In addition, in the sentence beginn...
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Article
Defective Epstein–Barr virus in chronic active infection and haematological malignancy
Epstein–Barr virus (EBV) infection is highly prevalent in humans and is implicated in various diseases, including cancer1,2. Chronic active EBV infection (CAEBV) is an intractable disease classified as a lymphopr...
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Article
Open AccessThe Epstein-Barr Virus BRRF1 Gene Is Dispensable for Viral Replication in HEK293 cells and Transformation
The Epstein-Barr virus (EBV) is a gamma-herpesvirus associated with several malignancies. It establishes a latent infection in B lymphocytes and is occasionally reactivated to enter the lytic cycle. Here we ex...
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Article
Open AccessA Herpesvirus Specific Motif of Epstein-Barr Virus DNA Polymerase Is Required for the Efficient Lytic Genome Synthesis
Epstein-Barr virus (EBV) is associated with several malignancies, including Burkitt lymphoma and nasopharyngeal carcinoma. To overcome such disorders, understanding the molecular mechanisms of the EBV replicat...
