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Article
Open AccessA genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy
Classic bladder exstrophy represents the most severe end of all human congenital anomalies of the kidney and urinary tract and is associated with bladder cancer susceptibility. Previous genetic studies identif...
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Article
3D analysis of bone mineral density in a cohort: age- and sex-related differences
Women have lower areal BMD (g/cm2) than men; however, the women have smaller-size bones. Our study showed that women ≤ 59 years have a hip volumetric BMD by DXA 3D similar to that of men of the same age. This mak...
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Article
Bone Metabolism in Inflammatory Bowel Disease and Celiac Disease
Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Sever...
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Article
Analysis of volumetric BMD in people with Down syndrome using DXA-based 3D modeling
We analyzed volumetric bone mineral density, by 3D analysis, in 76 people with Down syndrome and 76 controls. People with Down syndrome, particularly men, have a lower hip volumetric bone mineral density than ...
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Article
Non-synonymous WNT16 polymorphisms alleles are associated with different osteoarthritis phenotypes
Hereditary factors have a strong influence on osteoarthritis (OA). The Wnt pathway is involved in bone and cartilage homeostasis. Hence, we hypothesized that allelic variations of WNT16 could influence the OA ...
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Article
Osterix and RUNX2 are Transcriptional Regulators of Sclerostin in Human Bone
Sclerostin, encoded by the SOST gene, works as an inhibitor of the Wnt pathway and therefore is an important regulator of bone homeostasis. Due to its potent action as an inhibitor of bone formation, blocking scl...
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Article
Effect of Beta-Blockers on Bone Mineral Density, Bone Turnover Markers and Fractures: A Clinical Review
The increased sympathetic nervous activity causes bone loss, via an increase in osteoclastic bone resorption and a decrease in osteoblastic bone formation, suggesting an important regulating role for the SNS i...
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Article
Open Access"Single nucleotide polymorphisms of the OPG/RANKL system genes in primary hyperparathyroidism and their relationship with bone mineral density"
Primary hyperparathyroidism (PHPT) affects mainly cortical bone. It is thought that parathyroid hormone (PTH) indirectly regulates the activity of osteoclasts by means of the osteoprotegerin/ligand of the rece...
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Article
Guillain–Barré syndrome after rituximab in a patient with idiopathic thombocytopenic purpura: a causal association?
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Article
Open AccessGenetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women
Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study w...
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Article
Association of the F352V variant of the Klotho gene with bone mineral density
Klotho gene codes for a protein with glucuronidase activity and is thought to influence bone and vascular homeostasis. We studied the relationship of a common T/G polymorphism, resulting in a phenylalanine (F)...
