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Article
Pharmacokinetics and safety of a single intravenous dose of myo-inositol in preterm infants of 23–29 wk
Myo-inositol given to preterm infants with respiratory distress has reduced death, increased survival without bronchopulmonary dysplasia, and reduced severe retinopathy of prematurity in two randomized trials. Ph...
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Article
Apolipoprotein E genotype and outcome in infants with hypoxic–ischemic encephalopathy
Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele ha...
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Article
Open AccessInhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials
Inhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of...
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Article
Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants
Preterm infants with respiratory distress syndrome (RDS) given inositol had reduced bronchopulmonary dysplasia (BPD), death and severe retinopathy of prematurity (ROP). We assessed the safety and pharmacokinet...
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Article
Neonatal outcomes of moderately preterm infants compared to extremely preterm infants
Extremely preterm infants (EPT, <29 weeks’ gestation) represent only 0.9% of births in the United States; yet these infants are the focus of most published research. Moderately preterm neonates (MPT, 29–336/7 wee...
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Article
Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8
Twin studies suggest that genetic factors may account for up to 50% increased risk for necrotizing enterocolitis (NEC), but genome-wide association studies for NEC are lacking.
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Article
Open AccessExome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth
Previous studies have identified genetic variants associated with bronchopulmonary dysplasia (BPD) in extremely preterm infants. However, findings with genome-wide significance have been rare, and not replicat...
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Article
Prevalence and safety of diazoxide in the neonatal intensive care unit
Diazoxide is used to treat infants with persistent hypoglycemia, but the prevalence of its use and adverse effects are not well described. We report demographic and clinical characteristics of infants treated ...
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Article
Open AccessDisrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure
Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. Her...
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Article
Risk of development of treated retinopathy of prematurity in very low birth weight infants
Quantify the risk of treatment for retinopathy of prematurity (ROP) among infants meeting current U.S. screening guidelines.
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Article
Correction: Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessNeuroprotective therapies in the NICU in term infants: present and future
Outcomes of neonatal encephalopathy (NE) have improved since the widespread implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE in term and near-term infants has proven be...
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Article
Open AccessUse of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study
Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in...
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Article
Open AccessSocial distancing and extremely preterm births in the initial COVID-19 pandemic period
Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period.