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Article
Open AccessERCC1/BRCA1 expression and gene polymorphisms as prognostic and predictive factors in advanced NSCLC treated with or without cisplatin
The FAST was a factorial trial in first-line treatment of advanced non-small-cell lung cancer (NSCLC), addressing the role of replacing cisplatin with a non-platinum agent. The prognostic and predictive effect...
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Article
Open AccessBiological predictive factors in rectal cancer treated with preoperative radiotherapy or radiochemotherapy
We analysed the expression of microsatellite instability, p53, p21, vascular endothelial growth factor and thymidylate synthase (TS) in pretreatment biopsy specimens from 57 locally advanced rectal cancers. Th...
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Article
Functioning human insulinomas
Sixty-seven insulinomas were investigated by immunohistochemistry using site-directed antibodies against insulin, proinsulin, chromogranin A, HISL-19, and four proteins directly or indirectly involved in the ...
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Article
Ductal adenocarcinoma of the pancreas in MEN-1-patients
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Article
Neuroendokrine Tumoren des Magens Pathogenese, Klassifikation und Klinik*
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Article
Somatostatin Receptor Localization of Pancreatic Endocrine Tumors
n = 39) than conventional imaging studies (MRI, n = 25; CT, n = 13); 23 of 24 patients had positive octreotide s...
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Article
Well-differentiated endocrine tumours of the middle ear and of the hindgut have immunocytochemical and ultrastructural features in common
The immunocytochemical analysis of two cases of well-differentiated endocrine tumours (carcinoids) of the middle ear revealed predominant cell populations producing pancreatic polypeptide (PP)-related peptides...
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Article
Ultrastructural characterization of fundic endocrine cell hyperplasia associated with atrophic gastritis and hypergastrinaemia
Clinical and experimental evidence indicates that carcinoid tumours of the stomach fundic mucosa represent another example of hormone-dependent neoplasm, gastrin being the hormone involved in tumour induction....
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Article
Beckwith-Wiedemann syndrome: a quantitative, immunohistochemical study of pancreatic islet cell populations
The endocrine cell content of the pancreas of two cases of Beckwith-Wiedemann syndrome with islet cell adenomatosis were studied. Insulin, glucagon, somatostatin and pancreatic polypeptide cells were evaluated...
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Article
142 SUPERFICIAL CHRONIC GASTRITIS IN IDDM CHILDREN
Hypergastrinemia (↑ G), hypopepsinogenemia (↓ PG1) and gastric parietal cells autoantibodies (PCA) are considered as markers of atrophic gastritis which is a common complication in diabetic adults.
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Article
Altérations morphologiques et fonctionnelles muqueuses chez les patients porteurs de polypes gastriques
L’étude est consacrée à la relation entre polypes gastriques et lésions de la muqueuse (gastrite chronique atrophique, ulcère, cancer).
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Glucagon- and Glicentin-Producing Cells
Although the A-cell of pancreatic islets was identified around the beginning of this century (for a review of the landmarks in its identification, see Munger 1972; Wellmann and Volk 1977), this islet cell type ha...
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Article
Ultrastructural and histological study of 11 bronchial carcinoids
Seven of eleven bronchial carcinoids investigated showed cells with small granules resembling P cells which have already been described in human fetal and adult lung; two of these P cell tumours showed distinc...
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Article
Immunofluorescence, histochemical and ultrastructural studies for the detection of multiple endocrine polypeptide tumours of the pancreas
Four endocrine tumours of the pancreas associated respectively with the Zollinger-Ellison syndrome (1 case) and with hypoglycaemia (3 cases) have been investigated by means of immunofluorescence, employing ant...
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Article
Calcitonin- and ACTH-producing cells in a case of medullary carcinoma of the thyroid
The presence and distribution of calcitonin- and ACTH-producing cells have been investigated, by means of specific immunofluorescence in a case of medullary-type thyroid carcinoma associated with hyper-calcito...
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Article
Argyrophilic cells of the dog pancreas following different silver stains
L'esame comparativo dei risultati ottenuti dopo impregnazione argentica di sezioni di pancreas di cane con i metodi di Davenport (modificato daHellerström edHellman) e di Bodian ha rivelato notevoli diversità. L'...