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Article
Optimal processing of ESD specimens to avoid pathological artifacts
En bloc endoscopic submucosal dissection (ESD) has been recently introduced as a treatment for precancerous/neoplastic gastrointestinal conditions. The aim of the present study was histological assessment of e...
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Article
Interleukin 28B polymorphisms as predictors of sustained virological response in chronic hepatitis C: systematic review and meta-analysis
Polymorphism of interleukin 28B gene represents a powerful outcome predictor for interferon-based regimens in hepatitis C virus infection. However, some studies report conflicting results. The predictive value...
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Article
Open AccessGlutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts
A subset of human hepatocellular carcinomas (HCC) exhibit mutations of β-catenin gene CTNNB1 and overexpress Glutamine synthetase (GS). The CTNNB1-mutated HCC cell line HepG2 is sensitive to glutamine starvation ...
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Article
Role of immunoglobulin G fragment C receptor polymorphism-mediated antibody-dependant cellular cytotoxicity in colorectal cancer treated with cetuximab therapy
Antibody-dependent cellular cytotoxicity (ADCC), which is activated by effector cells via immunoglobulin G (IgG) fragment C receptors (FcRs), was proposed as a mechanism of cetuximab efficacy. Peripheral blood...
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Chapter and Conference Paper
Antiviral Cell-Mediated Immune Responses During Hepatitis B and Hepatitis C Virus Infections
Cell-mediated immune responses to hepatitis B (HBV) and hepatitis C virus (HCV) antigens are vigorous and multispecific in acute, self-limited infections. Moreover, the prevalent cytokine pattern of circulatin...
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Chapter
Cell-mediated Immune Response in Hepatitis C Virus (HCV) Infection: Are Different Strategies Adopted by HCV and Hepatitis B Virus to Persist?
Immune-mediated mechanisms play an important role in the pathogenesis of liver cell injury and viral persistence in both HCV and hepatitis B virus (HBV) infections. However, the different vigor of HLA class I ...
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Article
Role of the cell-mediated immune response in the pathogenesis of hepatitis B virus infection
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Article
Head-injured subjects aged over 50 years: correlations between variables of trauma and neuropsychologial follow-up
Neuropsychological follow-up was studied in 70 consecutive head-injured subjects aged over 50 years. Diffuse deterioration (28%), moderate deterioration (25%) and dementia (21%) were the most frequent sequelae...
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Chapter and Conference Paper
Immune pathogenesis of hepatitis B
Available information about the immune pathogenesis of HBV infection in man is very limited. However, the present availability of recombinant sources of the different HBV antigens expressed in the appropriate ...
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Chapter and Conference Paper
Fine specificity of the human T cell response to hepatitis B virus core antigen
The fine specificity of the human T cell response to the hepatitis B virus core antigen (HBcAg) was investigated in 23 patients with acute hepatitis B virus (HBV) infection using a panel of short synthetic pep...
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Article
The measurement of transmural pressure gradient at the esophageal varices by direct puncture during endoscopy
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Article
Ultrastructural characterization of fundic endocrine cell hyperplasia associated with atrophic gastritis and hypergastrinaemia
Clinical and experimental evidence indicates that carcinoid tumours of the stomach fundic mucosa represent another example of hormone-dependent neoplasm, gastrin being the hormone involved in tumour induction....
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Article
Altérations morphologiques et fonctionnelles muqueuses chez les patients porteurs de polypes gastriques
L’étude est consacrée à la relation entre polypes gastriques et lésions de la muqueuse (gastrite chronique atrophique, ulcère, cancer).