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Article
Open AccessRandomized phase-III study of low-dose cytarabine and etoposide + /− all-trans retinoic acid in older unfit patients with NPM1-mutated acute myeloid leukemia
The aim of this randomized clinical trial was to evaluate the impact of all-trans retinoic acid (ATRA) in combination with non-intensive chemotherapy in older unfit patients (> 60 years) with newly diagnosed NPM1
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Article
Reduced-toxicity conditioning for allogeneic hematopoietic cell transplantation in elderly or comorbid patients with AML using fludarabine, BCNU and melphalan: disease stage at transplant determines outcome
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Article
Early, risk-adapted treatment with fludarabine in Binet stage A chronic lymphocytic leukemia patients: results of the CLL1 trial of the German CLL study group
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Article
Open AccessAssessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants
Chronic myeloid leukemia (CML)-study IV was designed to explore whether treatment with imatinib (IM) at 400 mg/day (n=400) could be optimized by doubling the dose (n=420), adding interferon (IFN) (n=430) or cytar...
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Article
Open AccessCondensed versus standard schedule of high-dose cytarabine consolidation therapy with pegfilgrastim growth factor support in acute myeloid leukemia
The aim of this cohort study was to compare a condensed schedule of consolidation therapy with high-dose cytarabine on days 1, 2 and 3 (HDAC-123) with the HDAC schedule given on days 1, 3 and 5 (HDAC-135) as w...
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Article
Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: an analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH)
Primary mediastinal B-cell lymphoma (PMBL) is an aggressive extranodal B-cell non-Hodgkin's lymphoma with specific clinical, histopathological and genomic features. To characterize further the genotype of PMBL...
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Article
High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis
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Article
DNA microarray analysis in malignant lymphomas
Recently, DNA microarray technology has opened new avenues for the understanding of lymphomas. By hybridization of cDNA to arrays containing >10,000 different DNA fragments, this approach allows the simultaneo...
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Article
Klassische und molekulare Zytogenetik in der Hämatologie und Onkologie
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Article
Detection of secondary genetic aberrations in follicle center cell derived lymphomas: assessment of the reliability of comparative genomic hybridization and standard chromosome analysis
Secondary chromosomal aberrations in follicle center cell derived lymphomas (FCDL) usually involve gains and losses of genetic material and may be an important prognostic value. In the present study, we aimed ...
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Article
BCL10 is not the gene inactivated by mutation in the 1p22 deletion region in mantle cell lymphoma
The BCL10 gene has recently been cloned from the 1p22 breakpoint of the translocation t(1;14)(p22;q32) observed in mucosa-associated lymphoid tissue (MALT) lymphoma. BCL10 was shown to be a proapoptotic-signaling...
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Article
Primary gastric apoptosis-rich T-cell lymphoma co-expressing CD4, CD8, and cytotoxic molecules
In contrast to primary gastric lymphomas of B-cell type, little is known about primary gastric T-cell lymphomas. We describe three cases with remarkably similar features: diffuse growth, epitheliotropism, medi...
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Article
Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia
Deletions affecting the long arm of chromosome 6 (6q) are among the most commonly observed chromosomal aberrations in lymphoid malignancies and have been identified as adverse prognostic factor in subsets of t...
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Article
Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemia
The genetic alterations underlying the pathogenesis of B-cell chronic lymphocytic leukemia (B-CLL) are difficult to assess. Cytogenetic studies are hindered by the low in vitro mitotic activity of the tumor c...
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Chapter and Conference Paper
Molecular Cytogenetic Analysis of Low-Grade B-Cell Neoplasias: a Comparative Genomic Hybridization Study
Malignant tumors are characterized by deregulation of cell proliferation and differentiation, often induced by genomic alterations within the tumor cells (see Fischer et al., this volume). In acute leukemias, ...
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Chapter and Conference Paper
Fluorescence In Situ Hybridization for the Diagnosis and Follow-up of BCR-ABL Positive ALL
The BCR-ABL fusion, which is the molecular counterpart of the t(9;22), is the most common genetic abnormality in adult acute lymphoblastic leukemia (ALL) [1]. Due to its important diagnostic and prognostic sig...
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Chapter and Conference Paper
Designing Probe Sets for the Detection of Chromosome Abnormalities in Acute Myeloid Leukemia Using Fluorescence In Situ Hybridization
In recent years, the karyotype as a prognostic factor in acute myeloid leukemia (AML) has gained considerable interest. Clonal chromosome aberrations are identified in 50–60% of patients with AML (for review s...
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Chapter and Conference Paper
Detection of Chromosomal Abnormalities on Previously Stained Peripheral Blood and Bone Marrow Smears
Many hematological malignancies are associated with chromosomal aberrations that, in part, have important clinical significance. The detection of these abnormalities depends on the careful analysis of adequate...
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Article
Abstract