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Article
Open AccessReal-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes
Early insulin therapy is capable to achieve glycemic control and restore β-cell function in newly diagnosed type 2 diabetes (T2D), but its effect on cardiovascular outcomes in these patients remains unclear. I...
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Article
Open AccessPredicting in-hospital outcomes of patients with acute kidney injury
Acute kidney injury (AKI) is prevalent and a leading cause of in-hospital death worldwide. Early prediction of AKI-related clinical events and timely intervention for high-risk patients could improve outcomes....
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Article
Open AccessClinical relevance of glomerular IgM deposition in patients with lupus nephritis
The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort.
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Article
Open AccessScreening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8+ T cell responses in HLA-A transgenic mice
Since severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific T cells have been found to play essential roles in host immune protection and pathology in patients with coronavirus disease 2019 (CO...
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Article
Open AccessThree-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury
Exosomes derived from mesenchymal stem cells (MSC-exos) have been demonstrated with great potential in the treatment of multiple human diseases including acute kidney injury (AKI) by virtue of their intrinsic ...
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Article
Simple Colorimetric and Fluorometric Assay Based on 2,3-Naphthalenedialdehyde for Melatonin in Human Saliva
In this paper, 2,3-naphthalenedialdehyde (2,3-Nda) was selected as color reagent with colorimetric and fluorometric assay for detecting melatonin in human saliva. 2,3-naphthalenedialdehyde reacted with melaton...
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Article
Open AccessEpidemiology and outcomes of acute kidney injury in elderly chinese patients: a subgroup analysis from the EACH study
Information on acute kidney injury (AKI) in elderly hospitalized patients is limited. This study aims to assess the incidence, risk factors and outcomes of AKI in elderly Chinese patients.
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Article
FTY720 prevents progression of renal fibrosis by inhibiting renal microvasculature endothelial dysfunction in a rat model of chronic kidney disease
Recent studies have shown that chronic endothelial dysfunction can impair multiple aspects of renal physiology and, in turn, contribute to renal fibrosis. Sphingosine 1-phosphate (S1P) has been highlighted as ...
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Article
The influence of target material and thickness on proton energy and angular distribution
The paper has studied the influence of target material and thickness on energy and angular distributions of the protons generated by using an 800 nm, 60 fs, 0.24 J laser pulse to irradiate solid target foils. ...
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Article
Open AccessHigh glucose mediates endothelial-to-chondrocyte transition in human aortic endothelial cells
Vascular calcification is one of the common complications in diabetes mellitus. Many studies have shown that high glucose (HG) caused cardiovascular calcification, but its underlying mechanism is not fully und...
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Article
Open AccessAngiotensin II mediates the high-glucose-induced endothelial-to-mesenchymal transition in human aortic endothelial cells
Substantial evidence suggests that high glucose (HG) causes endothelial cell damage; however, the potential mechanism therein has yet to be clarified. The aim of this study was to investigate the influence of ...
