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Article
Open AccessHigh throughput, label-free isolation of circulating tumor cell clusters in meshed microwells
Extremely rare circulating tumor cell (CTC) clusters are both increasingly appreciated as highly metastatic precursors and virtually unexplored. Technologies are primarily designed to detect single CTCs and of...
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Article
Open AccessLabel-free microfluidic enrichment of cancer cells from non-cancer cells in ascites
The isolation of a patient's metastatic cancer cells is the first, enabling step toward treatment of that patient using modern personalized medicine techniques. Whereas traditional standard-of-care approaches ...
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Ovarian Cancer in Pregnancy
Ovarian cancer is extremely rare in pregnancy, but should be always considered when complex cysts are present and persist, especially when ascites and extra-ovarian nodularity are present. While epithelial can...
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Article
Open AccessMachine learning predicts individual cancer patient responses to therapeutic drugs with high accuracy
Precision or personalized cancer medicine is a clinical approach that strives to customize therapies based upon the genomic profiles of individual patient tumors. Machine learning (ML) is a computational metho...
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Open AccessEvidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that obs...
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Article
Open AccessHighly-accurate metabolomic detection of early-stage ovarian cancer
High performance mass spectrometry was employed to interrogate the serum metabolome of early-stage ovarian cancer (OC) patients and age-matched control women. The resulting spectral features were used to estab...
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Article
Open AccessTranscriptional override: a regulatory network model of indirect responses to modulations in microRNA expression
Documented changes in levels of microRNAs (miRNA) in a variety of diseases including cancer are leading to their development as early indicators of disease, and as a potential new class of therapeutic agents. ...
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Open AccessMolecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasis
While metastasis ranks among the most lethal of all cancer-associated processes, on the molecular level, it remains one of the least well understood. One model that has gained credibility in recent years is th...
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Open AccessGene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells
Accumulating evidence suggests that somatic stem cells undergo mutagenic transformation into cancer initiating cells. The serous subtype of ovarian adenocarcinoma in humans has been hypothesized to arise from ...
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Open AccessOvarian cancer detection from metabolomic liquid chromatography/mass spectrometry data by support vector machines
The majority of ovarian cancer biomarker discovery efforts focus on the identification of proteins that can improve the predictive power of presently available diagnostic tests. We here show that metabolomics,...
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Article
Open AccessAurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells
A large percentage of patients with recurrent ovarian cancer develop resistance to the taxane class of chemotherapeutics. While mechanisms of resistance are being discovered, novel treatment options and a bett...
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Article
Open AccessEpigenetic changes within the promoter region of the HLA-G gene in ovarian tumors
Previous findings have suggested that epigenetic-mediated HLA-G expression in tumor cells may be associated with resistance to host immunosurveillance. To explore the potential role of DNA methylation on HLA-G ex...
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Open AccessIdentification of candidate methylation-responsive genes in ovarian cancer
Aberrant methylation of gene promoter regions has been linked to changes in gene expression in cancer development and progression. Genes associated with CpG islands (CGIs) are especially prone to methylation, ...
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Article
Open AccessL1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas
Wide-spread hypomethylation of CpG dinucleotides is characteristic of many cancers. Retrotransposons have been identified as potential targets of hypomethylation during cellular transformation. We report the r...
