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Article
Open AccessSMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma
Bone morphogenetic protein (BMP) signaling is thought to play key roles in regulating the survival and maintenance of cancer stem cells (CSCs), which contribute to disease recurrences and treatment failures in...
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Article
Open AccessLysosomal drug sequestration as a mechanism of drug resistance in vascular sarcoma cells marked by high CSF-1R expression
Human angiosarcoma and canine hemangiosarcoma are thought to arise from vascular tissue or vascular forming cells based upon their histological appearance. However, recent evidence indicates a hematopoietic or...
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Article
Open AccessHemangiosarcoma and its cancer stem cell sub-population are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors
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Article
Open AccessConstitutive expression and roles of interleukin-8 in canine hemangiosarcoma
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Article
Open AccessChemosensitization of cancer cells by siRNA using targeted nanogel delivery
Chemoresistance is a major obstacle in cancer treatment. Targeted therapies that enhance cancer cell sensitivity to chemotherapeutic agents have the potential to increase drug efficacy while reducing toxic eff...
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Article
Open AccessIdentification of candidate methylation-responsive genes in ovarian cancer
Aberrant methylation of gene promoter regions has been linked to changes in gene expression in cancer development and progression. Genes associated with CpG islands (CGIs) are especially prone to methylation, ...
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Article
The sponge/Matrigel angiogenesis assay
It has become increasingly clear that definitive tests for angiogenesis require in vivo assays. Recently, the Matrigel plug assay has become the method of choice for many studies involving in vivo testing for ang...
