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Open AccessSTAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia
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Open AccessTwins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
Deregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is found in cancer with STAT5A/B controlling leukemic cell survival and disease progression. As ...
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Article
Open AccessPharmacologic inhibition of STAT5 in acute myeloid leukemia
The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK dri...
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Article
Transesophageal echocardiographic determinants of embolism in nonrheumatic atrial fibrillation
The purpose of the study was to determine the relation of transesophageal echocardiographic findings to symptoms of systemic embolism in patients with nonrheumatic atrial fibrillation. Transthoracic and transe...