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Article
APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease
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Article
Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo
Autism Spectrum Disorders (ASD) comprise a range of early age-onset neurodevelopment disorders with genetic heterogeneity. Most ASD related genes are involved in synaptic function, which is regulated by mature...
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Article
Open AccessAn ensemble learning model for continuous cognition assessment based on resting-state EEG
One critical manifestation of neurological deterioration is the sign of cognitive decline. Causes of cognitive decline include but are not limited to: aging, cerebrovascular disease, Alzheimer’s disease, and t...
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Article
Open AccessMechanical behavior and reloading reinforcement characteristics of fractured coal under low confining pressure
To study the basic mechanical behavior and the reloading reinforcement characteristics of fractured coal, conventional triaxial loading tests with different fissure angle were first carried out. On this basis,...
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Article
Open AccessTrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice
Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. Here we show that intravenous injection of Ab4B19, an agonistic antibody for the BDNF receptor TrkB, penet...
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Article
Open AccessAn App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments
A major obstacle in Alzheimer’s disease (AD) research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy. Transgenic mice overexpressing amyloid precurs...
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Article
Open AccessAstrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention
Memory consolidation requires astrocytic microdomains for protein recycling; but whether this lays a mechanistic foundation for long-term information storage remains enigmatic. Here we demonstrate that persist...
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Article
Open AccesshACE2 Fc-neutralization antibody cocktail provides synergistic protection against SARS-CoV-2 and its spike RBD variants
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Article
Open AccessHumoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines
SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain (RBD) and N-terminal domain (NTD). Here we report the humoral immune response to circulating SARS-CoV-2 variants, such...
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Article
Tunable Second Harmonic Generation in Antiferromagnetic Photonic Crystal with Graphene
The generation of second harmonic (SH) in the structure (SiO2/MnF2/graphene)N/ZrO2 has been investigated with the matrix transfer method. The theoretical simulation results show that the effect of the graphene (G...
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Chapter and Conference Paper
Research on Suitability of Solar Energy Utilization in Public Institutions Across the Country
This paper studies the suitability of solar energy utilization in public institutions across the country. The energy consumption of typical building is simulated by DeST, and the energy consumption per unit ar...
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Article
Enhancement of second harmonic generation in MnF2/graphene sandwich structure
We propose an efficient method for increasing the second harmonic (SH) generation by embedding the graphene (Gr) in SiO2/MnF2/ZnF2 sandwich structure. The external magnetic field is perpendicular to the surface o...
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Article
Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling
Brain-derived neurotrophic factor (BDNF) regulates diverse biological functions ranging from neuronal survival and differentiation during development to synaptic plasticity and cognitive behavior in the adult....
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Article
Open AccessExtracellular and intracellular cleavages of proBDNF required at two distinct stages of late-phase LTP
Although late-phase long-term potentiation (L-LTP) is implicated in long-term memory, its molecular mechanisms are largely unknown. Here we provide evidence that L-LTP can be divided into two stages: an induct...
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Article
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
Scientific advancement in neuroscience has not been effectively translated into therapies for neurological diseases. In general, 'toxin reducing' approaches (f...
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Article
Open AccessDisruption of specific GDNF receptor subtype signaling impairs cortical neuronal survival in Alzheimer’s brains
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Article
Open AccessActivity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior
Sleep homeostasis is characterized by a positive correlation between sleep length and intensity with the duration of the prior waking period. A causal role for brain-derived neurotrophic factor (BDNF) in sleep...
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Article
Open AccessPresynaptic protein synthesis required for NT-3-induced long-term synaptic modulation
Neurotrophins elicit both acute and long-term modulation of synaptic transmission and plasticity. Previously, we demonstrated that the long-term synaptic modulation requires the endocytosis of neurotrophin-rec...
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Article
Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons
The authors report that a dose of BDNF elicits very different signaling, morphological and synaptic responses in hippocampal neurons or slices, depending on whether it is applied all at once or gradually.
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Article
Open AccessMultiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
Proneurotrophins and mature neurotrophins elicit opposite effects via the p75 neurotrophin receptor (p75NTR) and Trk tyrosine kinase receptors, respectively; however the molecular roles of proneurotrophins in the...
