Acute Retinal Necrosis and Progressive Outer Retinal Necrosis

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Inflammatory and Infectious Ocular Disorders

Part of the book series: Retina Atlas ((RA))

Abstract

Necrotizing retinopathies, including acute retinal necrosis (ARN) and progressive outer retinal necrosis (PORN), are a group of uncommon posterior segment complications associated with infections caused by the herpes virus. ARN was first described in 1971 by Urayama et al., Japanese ophthalmologists who termed the condition as Kirisawa uveitis and described it as acute unilateral panuveitis associated with optic neuritis and retinal panarteritis in healthy adults, with subsequent procession to diffuse necrotizing retinitis and/or subsequent rhegmatogenous retinal detachment (RRD) (Urayama et al. 1971). Standard diagnostic criteria for ARN were published by the American Uveitis Committee (Table 27.1) (Holland 1994).

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References

  • Asano S, Yoshikawa T, Kimura H, Enomoto Y, Ohashi M, Terasaki H, Nishiyama Y. Monitoring herpesvirus DNA in three cases of acute retinal necrosis by real-time PCR. J Clin Virol. 2004;29:206–9.

    Article  CAS  Google Scholar 

  • Austin RB. Progressive outer retinal necrosis syndrome: a comprehensive review of its clinical presentation, relationship to immune system status, and management. Clin Eye Vis Care. 2000;12:119–29.

    Article  CAS  Google Scholar 

  • Blumenkranz MS, Culbertson WW, Clarkson JG, Dix R. Treatment of the acute retinal necrosis syndrome with intravenous acyclovir. Ophthalmology. 1986;93:296–300.

    Article  CAS  Google Scholar 

  • Cochrane TF, Silvestri G, McDowell C, Foot B, McAvoy CE. Acute retinal necrosis in the United Kingdom: results of a prospective surveillance study. Eye (Lond). 2012;26:370–7; quiz 378.

    Article  CAS  Google Scholar 

  • Duker JS, Blumenkranz MS. Diagnosis and management of the acute retinal necrosis (ARN) syndrome. Surv Ophthalmol. 1991;35:327–43.

    Article  CAS  Google Scholar 

  • Engstrom RE Jr, Holland GN, Margolis TP, Muccioli C, Lindley JI, Belfort R Jr, Holland SP, Johnston WH, Wolitz RA, Kreiger AE. The progressive outer retinal necrosis syndrome. A variant of necrotizing herpetic retinopathy in patients with AIDS. Ophthalmology. 1994;101:1488–502.

    Article  Google Scholar 

  • Forster DJ, Dugel PU, Frangieh GT, Liggett PE, Rao NA. Rapidly progressive outer retinal necrosis in the acquired immunodeficiency syndrome. Am J Ophthalmol. 1990;110:341–8.

    Article  CAS  Google Scholar 

  • Gore DM, Gore SK, Visser L. Progressive outer retinal necrosis: outcomes in the intravitreal era. Arch Ophthalmol. 2012;130:700–6.

    Article  Google Scholar 

  • Hillenkamp J, Nolle B, Bruns C, Rautenberg P, Fickenscher H, Roider J. Acute retinal necrosis: clinical features, early vitrectomy, and outcomes. Ophthalmology. 2009;116:1971–1975.e1972.

    Article  Google Scholar 

  • Holland GN. Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society. Am J Ophthalmol. 1994;117:663–7.

    Article  CAS  Google Scholar 

  • Holland GN, Cornell PJ, Park MS, Barbetti A, Yuge J, Kreiger AE, Kaplan HJ, Pepose JS, Heckenlively JR, Culbertson WW, et al. An association between acute retinal necrosis syndrome and HLA-DQw7 and phenotype Bw62, DR4. Am J Ophthalmol. 1989;108:370–4.

    Article  CAS  Google Scholar 

  • Iwahashi-Shima C, Azumi A, Ohguro N, Okada AA, Kaburaki T, Goto H, Sonoda KH, Namba K, Mizuki N, Mochizuki M. Acute retinal necrosis: factors associated with anatomic and visual outcomes. Jpn J Ophthalmol. 2013;57:98–103.

    Article  Google Scholar 

  • Jacobson MA, Berger TG, Fikrig S, Becherer P, Moohr JW, Stanat SC, Biron KK. Acyclovir-resistant varicella zoster virus infection after chronic oral acyclovir therapy in patients with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1990;112:187–91.

    Article  CAS  Google Scholar 

  • Kawaguchi T, Spencer DB, Mochizuki M. Therapy for acute retinal necrosis. Semin Ophthalmol. 2008;23:285–90.

    Article  Google Scholar 

  • Lau CH, Missotten T, Salzmann J, Lightman SL. Acute retinal necrosis features, management, and outcomes. Ophthalmology. 2007;114:756–62.

    Article  Google Scholar 

  • Meghpara B, Sulkowski G, Kesen MR, Tessler HH, Goldstein DA. Long-term follow-up of acute retinal necrosis. Retina. 2010;30:795–800.

    Article  Google Scholar 

  • Moorthy RS, Weinberg DV, Teich SA, Berger BB, Minturn JT, Kumar S, Rao NA, Fowell SM, Loose IA, Jampol LM. Management of varicella zoster virus retinitis in AIDS. Br J Ophthalmol. 1997;81:189–94.

    Article  CAS  Google Scholar 

  • Palay DA, Sternberg P Jr, Davis J, Lewis H, Holland GN, Mieler WF, Jabs DA, Drews C. Decrease in the risk of bilateral acute retinal necrosis by acyclovir therapy. Am J Ophthalmol. 1991;112:250–5.

    Article  CAS  Google Scholar 

  • Rochat C, Polla BS, Herbort CP. Immunological profiles in patients with acute retinal necrosis. Graefes Arch Clin Exp Ophthalmol. 1996;234:547–52.

    Article  CAS  Google Scholar 

  • Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, Ehlers JP. Diagnosis and treatment of acute retinal necrosis: a report by the American Academy of Ophthalmology. Ophthalmology. 2017;124:382–92.

    Article  Google Scholar 

  • Spaide RF, Martin DF, Teich SA, Katz A, Toth I. Successful treatment of progressive outer retinal necrosis syndrome. Retina. 1996;16:479–87.

    Article  CAS  Google Scholar 

  • Sternberg P Jr, Han DP, Yeo JH, Barr CC, Lewis H, Williams GA, Mieler WF. Photocoagulation to prevent retinal detachment in acute retinal necrosis. Ophthalmology. 1988;95:1389–93.

    Article  Google Scholar 

  • Sugita S, Ogawa M, Shimizu N, Morio T, Ohguro N, Nakai K, Maruyama K, Nagata K, Takeda A, Usui Y, Sonoda KH, Takeuchi M, Mochizuki M. Use of a comprehensive polymerase chain reaction system for diagnosis of ocular infectious diseases. Ophthalmology. 2013;120:1761–8.

    Article  Google Scholar 

  • Takase H, Okada AA, Goto H, Mizuki N, Namba K, Ohguro N, Sonoda KH, Tomita M, Keino H, Kezuka T, Kubono R, Mizuuchi K, Shibuya E, Takahashi H, Yanai R, Mochizuki M. Development and validation of new diagnostic criteria for acute retinal necrosis. Jpn J Ophthalmol. 2015;59:14–20.

    Article  CAS  Google Scholar 

  • Urayama A, Yamada N, Sasaki T. Unilateral acute retinal uveitis with retinal periarteritis and detachment. Jpn J Clin Ophthalmol. 1971;25:607–19.

    Google Scholar 

  • Wong RW, Jumper JM, McDonald HR, Johnson RN, Fu A, Lujan BJ, Cunningham ET Jr. Emerging concepts in the management of acute retinal necrosis. Br J Ophthalmol. 2013;97:545–52.

    Article  Google Scholar 

  • Yin PD, Kurup SK, Fischer SH, Rhee HH, Byrnes GA, Levy-Clarke GA, Buggage RR, Nussenblatt RB, Mican JM, Wright ME. Progressive outer retinal necrosis in the era of highly active antiretroviral therapy: successful management with intravitreal injections and monitoring with quantitative PCR. J Clin Virol. 2007;38:254–9.

    Article  CAS  Google Scholar 

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Correspondence to Atsunobu Takeda .

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Takeda, A., Arima, M., Ishikawa, K., Hasegawa, E., Murakami, Y., Sonoda, KH. (2020). Acute Retinal Necrosis and Progressive Outer Retinal Necrosis. In: Yu, H. (eds) Inflammatory and Infectious Ocular Disorders. Retina Atlas. Springer, Singapore. https://doi.org/10.1007/978-981-13-8546-9_27

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  • DOI: https://doi.org/10.1007/978-981-13-8546-9_27

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