10 Result(s)
within
Anxo Vidal
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessDeep optoacoustic localization microangiography of ischemic stroke in mice
Super-resolution optoacoustic imaging of microvascular structures deep in mammalian tissues has so far been impeded by strong absorption from densely-packed red blood cells. Here we devised 5 µm biocompatible ...
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Article
Open AccessAuthor Correction: A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer
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Open AccessA nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer
Despite therapeutic advancements, oral cavity squamous cell carcinoma (OCSCC) remains a difficult disease to treat. Systemic platinum-based chemotherapy often leads to dose-limiting toxicity (DLT), affecting q...
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Open AccessO-GlcNAcylated p53 in the liver modulates hepatic glucose production
p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we...
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Open AccessAuthor Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessIdentification and characterization of Cardiac Glycosides as senolytic compounds
Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Car...
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Open AccessPhosphorylable tyrosine residue 162 in the double-stranded RNA-dependent kinase PKR modulates its interaction with SUMO
Activated dsRNA-dependent serine/threonine kinase PKR phosphorylates the alpha subunit of eukaryotic initiation factor 2 (eIF2α), resulting in a shut-off of general translation, induction of apoptosis, and inh...
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Open AccessCorrection: Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress
Nature Communications 8: Article number:15111 (2017); Published: 8 May 2017; Updated: 16 June 2017 The affiliation details for Paula Iruzubieta and Javier Crespo are incorrect in this Article. The correct affi...
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Open AccessHepatic p63 regulates steatosis via IKKβ/ER stress
p53 family members control several metabolic and cellular functions. The p53 ortholog p63 modulates cellular adaptations to stress and has a major role in cell maintenance and proliferation. Here we show that ...
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Open AccessCell senescence is an antiviral defense mechanism
Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activator...
