12 Result(s)

Article

Impact of Upadacitinib on Laboratory Parameters and Related Adverse Events in Patients with RA: Integrated Data Up to 6.5 Years

Upadacitinib (UPA) is a Janus kinase inhibitor that has demonstrated efficacy in moderate-to-severe rheumatoid arthritis (RA) with an acceptable safety profile. We investigated laboratory parameter changes in ...

Christina Charles-Schoeman, Jon T. Giles, Nancy E. Lane… in Rheumatology and Therapy (2024)

Article

Correction to: Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment

James Oliver, Nisha Nair, Gisela Orozco, Samantha Smith… in Arthritis Research & Therapy (2021)

Article

Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment

Despite the success of TNF-inhibitor therapy in rheumatoid arthritis treatment, up to 40% of patients fail to respond adequately. This study aimed to identify transcriptome-based biomarkers of adalimumab respo...

James Oliver, Nisha Nair, Gisela Orozco, Samantha Smith… in Arthritis Research & Therapy (2021)

Article

Rheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only study

We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tum...

Ariana Montes, Eva Perez-Pampin, Federico Navarro-Sarabia… in Arthritis Research & Therapy (2015)

Article

A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis

Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL (Receptor...

Rachel Knevel, Diederik PC de Rooy, Tore Saxne… in Arthritis Research & Therapy (2014)

Article

Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

In many European countries, restrictions exist around the prescription of anti-tumor necrosis factor (anti-TNF) treatments for rheumatoid arthritis (RA). Eligibility and response to treatment is assessed by us...

Darren Plant, Ibrahim Ibrahim, Mark Lunt, Stephen Eyre… in Arthritis Research & Therapy (2012)

Article

Overlap** genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease

Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is now ...

Stephen Eyre, Anne Hinks, John Bowes, Edward Flynn… in Arthritis Research & Therapy (2010)

Article

Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initia...

Sindhu T Mohanty, Lucksy Kottam, Alessandra Gambardella… in Arthritis Research & Therapy (2010)

Article

Complex genetic association of 6q23 with autoimmune rheumatic conditions

In the paper by Dieguez-Gonzalez and colleagues in the present issue of Arthritis Research & Therapy, the results of a detailed genetic investigation of the recently identified rheumatoid arthritis and systemic l...

James R Maxwell, Isobel R Gowers, Anthony G Wilson in Arthritis Research & Therapy (2009)

Article

Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis

A feature of rheumatoid arthritis (RA) is an imbalance between proinflammatory and anti-inflammatory cytokines. Several recent studies have implicated polymorphism in the IL-4 signalling pathway in the develop...

Ioanna Marinou, Simon H Till, David J Moore… in Arthritis Research & Therapy (2008)

Article

The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis

An important feature of autoimmune diseases is the overlap of pathophysiological characteristics. Clustering of autoimmune diseases in families suggests that genetic variants may contribute to autoimmunity. Th...

Ioanna Marinou, Douglas S Montgomery, Marion C Dickson… in Arthritis Research & Therapy (2007)

Article

Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis

Several recent publications have established a strong association between anti-cyclic citrullinated peptide antibody (anti-CCP)-positive rheumatoid arthritis (RA) and carriage of shared epitope (SE) alleles. A...

Devesh Mewar, Annabel Coote, David J Moore, Ioanna Marinou… in Arthritis Research & Therapy (2006)