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Article
Open AccessTotal marrow irradiation versus total body irradiation using intensity-modulated helical tomotherapy
Total body irradiation (TBI) is often a component of the conditioning regimen prior to hematopoietic stem cell transplantation in patients with hematological malignancies. However, total marrow irradiation (TM...
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Article
Open AccessWhole body irradiation with intensity-modulated helical tomotherapy prior to haematopoietic stem cell transplantation: analysis of organs at risk by dose and its effect on blood kinetics
Intensity-modulated helical tomotherapy (HT) is a promising technique in preparation for bone marrow transplantation. Nevertheless, radiation-sensitive organs can be substantially compromised due to suboptimal...
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Article
Open AccessTwo cases of EBV infection preceding lymphoma
Infection of lymphocytes with the Epstein-Barr virus (EBV) is a well-documented risk factor for develo** lymphoma. The incidence of EBV positivity in lymphoma depends on the subtype and can range from 10% in...
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Article
Open AccessBlastic plasmacytoid dendritic-cell neoplasia: a challenging case report
Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an extremely rare disease that originates from dendritic cells and is associated with a poor overall survival (OS). Diagnostic and therapeutic standards ...
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Article
Open AccessThe PI3Kδ inhibitor idelalisib impairs the function of human dendritic cells
The PI3Kδ-inhibitor Idelalisib is approved for the treatment of Non-Hodgkin lymphoma. However, its use has been decreased within the last years due to deleterious infections such as cytomegalovirus and pneumoc...
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Article
Open AccessElotuzumab spares dendritic cell integrity and functionality
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Article
Open AccessClinical and immunological effects of mRNA vaccines in malignant diseases
In vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and highly efficient class of drugs. Several recently published studies emphasize the potential efficacy of mRNA vaccines in trea...
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Article
Open AccessG-quadruplexes: a promising target for cancer therapy
DNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This stru...
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Article
The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib
Increased numbers of immunosuppressive myeloid derived suppressor cells (MDSCs) correlate with a poor prognosis in cancer patients. Tyrosine kinase inhibitors (TKIs) are used as standard therapy for the treat...
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Article
Open AccessAnalysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma
Multiple myeloma (MM) is a clonal B cell malignancy characterized by proliferation of malignant plasma cells in the bone marrow. Despite high-dose melphalan therapy with autologous stem cell transplantation (A...
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Article
Imatinib mesylate and nilotinib affect MHC-class I presentation by modulating the proteasomal processing of antigenic peptides
Imatinib (IM) has been described to modulate the function of dendritic cells and T lymphocytes and to affect the expression of antigen in CML cells. In our study, we investigated the effect of the tyrosine kin...
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Article
Tumorvakzinierung beim metastasierten Nierenzellkarzinom
Das Nierenzellkarzinom (NCC) zählt zu den immunogenen Tumoren, die kaum auf eine Strahlen- oder Chemotherapie ansprechen, so dass weitere, neue Therapieoptionen dringend notwendig sind. Zur Behandlung des NCC ...
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Article
Generation of antigen-specific CTL responses using RGS1 mRNA transfected dendritic cells
Advances in tumor immunology and Identification of tumor-associated antigens (TAAs) provide a basis for the development of novel immunotherapies to treat malignant diseases. In order to identify novel TAAs, we...