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Article
Open AccessAnxiety in adults with asthma during the coronavirus disease 2019 pandemic: a Canadian perspective
Asthma is a chronic airway inflammatory disease that affects millions of Canadians and often contributes to higher levels of anxiety among patients. Since the coronavirus disease 2019 (COVID-19) pandemic was a...
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Article
Open AccessUtility of eConsults for COVID-19 vaccine-related concerns in Ontario: a cross-sectional analysis
The Champlain BASE™ and Ontario eConsult services are virtual platforms that serve to facilitate contact between primary care providers and specialists across Ontario, relaying patient-specific questions to re...
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Article
Open AccessCanadian multidisciplinary expert consensus on the use of biologics in upper airways: a Delphi study
Chronic rhinosinusitis with nasal polyposis (CRSwNP) often coexists with lower airway disease. With the overlap between upper and lower airway disease, optimal management of the upper airways is undertaken in ...
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Article
Open AccessAsymptomatic surveillance testing for COVID-19 in health care professional students: lessons learned from a low prevalence setting
The novel coronavirus disease of 2019 (COVID-19) pandemic has severely impacted the training of health care professional students because of concerns of potential asymptomatic transmission to colleagues and vu...
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Article
Open AccessMinimization of ragweed allergy immunotherapy costs through use of the sublingual immunotherapy tablet in Canadian children with allergic rhinoconjunctivitis
Allergy immunotherapy (AIT), in the form of subcutaneous immunotherapy (SCIT) with alum-precipitated aqueous extracts, SCIT with a modified ragweed pollen allergen tyrosine adsorbate (MRPATA; Pollinex®-R), or a s...
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Article
Open AccessSmall-molecule metabolome identifies potential therapeutic targets against COVID-19
Respiratory viruses are transmitted and acquired via the nasal mucosa, and thereby may influence the nasal metabolome composed of biochemical products produced by both host cells and microbes. Studies of the n...
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Article
Open AccessClarifying SABA overuse: Translating Canadian Thoracic Society guidelines into clinical practice
Patients with asthma frequently over rely on short-acting beta-agonists (SABA) to treat acute symptoms. This can adversely impact quality of life and increase the risk of exacerbations. SABA overuse is also as...
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Article
Indoor exposure to phthalates and polycyclic aromatic hydrocarbons (PAHs) to Canadian children: the Kingston allergy birth cohort
Canadian children are widely exposed to phthalates and polycyclic aromatic hydrocarbons (PAHs) from indoor sources. Both sets of compounds have been implicated in allergic symptoms in children.
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Article
Open AccessRandomized controlled trial of ragweed sublingual immunotherapy tablet in the subpopulation of Canadian children and adolescents with allergic rhinoconjunctivitis
Post hoc analyses of randomized placebo-controlled trials have demonstrated efficacy and tolerability of the ragweed sublingual immunotherapy (SLIT)-tablet in Canadian adults with ragweed pollen-induced allerg...
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Article
Open AccessRupatadine to prevent local allergic reactions to sublingual allergy immunotherapy: a case series
Sublingual immunotherapy tablets (SLIT-T) are an effective treatment for allergic rhinitis (AR), but some patients experience local allergic reactions (LAR) in the first few weeks of treatment that can lead to...
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Article
Open AccessSublingual immunotherapy tablet: a cost-minimizing alternative in the treatment of tree pollen-induced seasonal allergic rhinitis in Canada
A cost-minimization analysis (CMA) was performed to evaluate the economic implications of introducing the SQ Tree sublingual immunotherapy (SLIT)-tablets marketed as ITULATEK® (Health Canada regulatory approva...
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Article
Open AccessClinical validation of controlled exposure to house dust mite in the environmental exposure unit (EEU)
The Environmental Exposure Unit (EEU), a controlled allergen exposure model of allergic rhinitis (AR), has traditionally utilized seasonal allergens. We sought to clinically validate the use of house dust mite...
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Article
Open AccessCOVID-19 vaccine testing & administration guidance for allergists/immunologists from the Canadian Society of Allergy and Clinical Immunology (CSACI)
Safe and effective vaccines provide the first hope for mitigating the devastating health and economic impacts resulting from coronavirus disease 2019 (COVID-19) and related public health orders. Recent case re...
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Article
Open AccessCorrection to: Patient Engagement Partnerships in Clinical Trials: Development of Patient Partner and Investigator Decision Aids
In the original version of the
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Article
Open AccessPatient Engagement Partnerships in Clinical Trials: Development of Patient Partner and Investigator Decision Aids
A 2017 systematic review suggested patient engagement in clinical trials has been limited, with little active engagement in trial design or data analysis, interpretation or dissemination. Additionally, there r...
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Article
Open AccessPractical guide for evaluation and management of beta-lactam allergy: position statement from the Canadian Society of Allergy and Clinical Immunology
The vast majority of individuals labelled as allergic are not deemed truly allergic upon appropriate assessment by an allergist. A label of beta-lactam allergy carries important risks for individual and public...
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Article
Utility of Environmental Exposure Unit Challenge Protocols for the Study of Allergic Rhinitis Therapies
This paper explores how the Environmental Exposure Unit (EEU) experimental model can be used to further our understanding of pharmacotherapies and immunotherapies for the treatment of allergic rhinitis (AR).
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Article
Open AccessTowards definitive management of allergic rhinitis: best use of new and established therapies
Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa impacting up to 25% of Canadians. The standard of care for AR includes a treatment plan that takes into account patient preferences, the se...
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Article
Open AccessPatient and physician perceptions of seasonal allergic rhinitis and allergen immunotherapy: a parallel physician patient survey
The Allergy Patient Identification for Immunotherapy (AsPIRe) program was a parallel physician and patient survey. The objectives were to examine physician and patient perceptions of seasonal allergy symptoms ...
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Introduction to Anaphylaxis Essentials
Anaphylaxis is a severe life-threatening systemic allergic reaction. It is mediated by IgE and predominantly involves mast cells and basophils. The most common triggers are food, insect stings, medications, an...
