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Article
Open AccessAn Integrative multi-lineage model of variation in leukopoiesis and acute myelogenous leukemia
Acute myelogenous leukemia (AML) progresses uniquely in each patient. However, patients are typically treated with the same types of chemotherapy, despite biological differences that lead to differential respo...
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Reference Work Entry In depth
Applied Control Theory for Biological Processes
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Article
Experimental Design for Dynamics Identification of Cellular Processes
We address the problem of using nonlinear models to design experiments to characterize the dynamics of cellular processes by using the approach of the Maximally Informative Next Experiment (MINE), which was in...
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Article
A Global Parallel Model Based Design of Experiments Method to Minimize Model Output Uncertainty
Model-based experiment design specifies the data to be collected that will most effectively characterize the biological system under study. Existing model-based design of experiment algorithms have primarily r...
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Article
Ischemia’s Proliferative and Morphological Effects: Analyzing the Roles of Hypoxia, Hypercapnia, and Glucose
In ischemic tissues, oxygen (O2) and glucose become depleted while cells concomitantly promote carbon dioxide (CO2) and waste accumulation. Hypoxia has become a topic of great interest. Notably, these insults, in...
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Article
Investigating the Role of Ischemia vs. Elevated Hydrostatic Pressure Associated with Acute Obstructive Uropathy
Obstructive uropathy can cause irreversible renal damage. It has been hypothesized that elevated hydrostatic pressure within renal tubules and/or renal ischemia contributes to cellular injury following obstruc...
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Article
Open AccessSBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool
It has long been recognized that sensitivity analysis plays a key role in modeling and analyzing cellular and biochemical processes. Systems biology markup language (SBML) has become a well-known platform for ...