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Article
Open AccessRNA-sequencing predicts a role of androgen receptor and aldehyde dehydrogenase 1A1 in osteosarcoma lung metastases
One-third of pediatric patients with osteosarcoma (OS) develop lung metastases (LM), which is the primary predictor of mortality. While current treatments of patients with localized bone disease have been succ...
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Article
When can we reconstruct the ancestral state? Beyond Brownian motion
Reconstructing the ancestral state of a group of species helps answer many important questions in evolutionary biology. Therefore, it is crucial to understand when we can estimate the ancestral state accuratel...
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Article
On the convergence of the maximum likelihood estimator for the transition rate under a 2-state symmetric model
Maximum likelihood estimators are used extensively to estimate unknown parameters of stochastic trait evolution models on phylogenetic trees. Although the MLE has been proven to converge to the true value in t...
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Article
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
Somatic mutations in tet methylcytosine dioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies1–7. In both humans and mice, TET2 deficiency leads t...
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Chapter and Conference Paper
Learning from Non-iid Data: Fast Rates for the One-vs-All Multiclass Plug-in Classifiers
We prove new fast learning rates for the one-vs-all multiclass plug-in classifiers trained either from exponentially strongly mixing data or from data generated by a converging drifting distribution. These are...
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Article
Experimental Design for Dynamics Identification of Cellular Processes
We address the problem of using nonlinear models to design experiments to characterize the dynamics of cellular processes by using the approach of the Maximally Informative Next Experiment (MINE), which was in...
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Chapter and Conference Paper
Generalization and Robustness of Batched Weighted Average Algorithm with V-Geometrically Ergodic Markov Data
We analyze the generalization and robustness of the batched weighted average algorithm for V-geometrically ergodic Markov data. This algorithm is a good alternative to the empirical risk minimization algorithm...
