10 Result(s)
within
Karen M. Haberstroh
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Article
Increased Osteoblast and Decreased Smooth Muscle Cell Adhesion on Biologically-inspired Carbon Nanofibers
Osteoblast (the bone-forming cells) and smooth muscle cell adhesion was investigated on carbon nanofiber formulations of various diameters (specifically, from 60 to 200 nm) and surface energies (from 25 to 140...
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Article
An Investigation of Nano-structured Polymers for Use as Bladder Tissue Replacement Constructs
Conventionally, studies investigating the design of synthetic bladder wall substitutes have involved polymers with micro-dimensional structures. Since the body is made up of nano-structured components (e.g., extr...
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Article
Small Diameter, High Surface Energy Carbon Nanofiber Formulations that Selectively Increase Osteoblast function
The objective of the presentin vitro study was to investigate the potential of carbon nanofibers, which have nanometer dimensions similar to hydroxyapatite crystals in physiological bone, for orthopedic applicati...
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Article
An In Vitro Study of Nano-fiber Polymers for Guided Vascular Regeneration
Biomaterials that successfully integrate into surrounding tissue should match not only the tissue’s mechanical properties, but also the dimensions of the associated nano-structured extra-cellular matrix (ECM) ...
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Article
Ischemia’s Proliferative and Morphological Effects: Analyzing the Roles of Hypoxia, Hypercapnia, and Glucose
In ischemic tissues, oxygen (O2) and glucose become depleted while cells concomitantly promote carbon dioxide (CO2) and waste accumulation. Hypoxia has become a topic of great interest. Notably, these insults, in...
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Article
Investigating the Role of Ischemia vs. Elevated Hydrostatic Pressure Associated with Acute Obstructive Uropathy
Obstructive uropathy can cause irreversible renal damage. It has been hypothesized that elevated hydrostatic pressure within renal tubules and/or renal ischemia contributes to cellular injury following obstruc...
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Chapter
Vascular Cell Responses to Fluid Shear Stress
The development of several vascular diseases is linked to both blood flowproperties and cellular behavior in the arterial and venous systems. For instance, atherosclerosis development is dependent on the blood...
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Article
Non-Uniform Flow Behavior in a Parallel Plate Flow Chamber Alters Endothelial Cell Responses
Arterial flow characteristics determine vessel health by modulating vascular endothelial cells. One system used to study these interactions is the parallel plate flow chamber. The present in vitro study quantifie...
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Article
Carbon Nanofiber Surface Roughness Increases Osteoblast Adhesion
The present study demonstrated for the first time desirable cytocompatibility properties of carbon nanofibers pertinent for bone prosthetic applications. Specifically, osteoblast (boneforming cells), fibroblas...
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Article
In Vitro Vascular Cell Adhesion and Proliferation on Alkaline Degraded Poly-lactic/glycolic Acid Polymers
The objective of the present in vitro study was to determine vascular endothelial and smooth muscle cell responses to poly(lactic-co-glycolic acid) (PLGA) films that were exposed apriori to various degrees of ...
