19 Result(s)
-
Article
Open AccessEnhanced plant-derived vesicles for nucleotide delivery for cancer therapy
Small RNAs (microRNAs [miRNAs] or small interfering RNAs [siRNAs]) are effective tools for cancer therapy, but many of the existing carriers for their delivery are limited by low bioavailability, insufficient ...
-
Article
Open AccessIn situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy
In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and post-neoadjuvant chemotherapy (NACT) tissues from patients w...
-
Article
Open AccessSpatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells
To understand how malignant tumors develop, we tracked cell membrane, nuclear membrane, spindle, and cell cycle dynamics in polyploid giant cancer cells (PGCCs) during the formation of high-grade serous carcin...
-
Article
Open AccessIntegrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors
Low-grade serous ovarian cancer (LGSOC) is a rare disease that occurs more frequently in younger women than those with high-grade disease. The current treatment is suboptimal and a better understanding of the ...
-
Article
Open AccessIL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming
To understand the role of polyploid giant cancer cells (PGCCs) in drug resistance and disease relapse, we examined the mRNA expression profile of PGCCs following treatment with paclitaxel in ovarian cancer cel...
-
Article
Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity
Ferroptosis, a form of regulated cell death triggered by lipid peroxidation, was recently identified as an important mechanism in radiotherapy (RT)-mediated tumor suppression and radioresistance, although the ...
-
Article
The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis
Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer progression, but the underlying mechanisms are poorly understood. The purpose of this study was to elucidate mecha...
-
Article
Identifying and targeting angiogenesis-related microRNAs in ovarian cancer
Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional a...
-
Article
Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis
Angiogenesis is critical to cancer development and metastasis. However, anti-angiogenic agents have only had modest therapeutic success, partly due to an incomplete understanding of tumor endothelial cell (EC)...
-
Article
EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis
EGFL6, a member of the EGF-like superfamily, plays an important role during embryonic development and has been implicated in promotion of tumor angiogenesis without affecting wound healing. There is very littl...
-
Article
Open AccessImmune cell profiling in cancer: molecular approaches to cell-specific identification
The immune system has many important regulatory roles in cancer development and progression. Given the emergence of effective immune therapies against many cancers, reliable predictors of response are needed. ...
-
Article
Open AccessEndothelial cell malignancies: new insights from the laboratory and clinic
Endothelial cell malignancies are rare in the Western world and range from intermediate grade hemangioendothelioma to Kaposi sarcoma to aggressive high-grade angiosarcoma that metastasize early and have a high...
-
Article
Ovarian cancer
Ovarian cancer is not a single disease and can be subdivided into at least five different histological subtypes that have different identifiable risk factors, cells of origin, molecular compositions, clinical ...
-
Article
A framework for a personalized surgical approach to ovarian cancer
The standard treatment for advanced-stage ovarian cancer is upfront cytoreductive surgery, and the extent of residual disease after surgery correlates with response to adjuvant therapy and disease outcomes. Th...
-
Article
Latest research and treatment of advanced-stage epithelial ovarian cancer
Late-stage distribution and bulky intraperitioneal disease are the hallmarks of ovarian cancer presentation, which is managed primarily by surgical resection and chemotherapy. However, advances in surgical res...
-
Article
Personalized cancer medicine—advances and socio-economic challenges
The use of therapy that is truly targeted to the needs and biological requirements of an individual patient is an aim for many in the oncology field. Jackson and Sood discuss the implications of targeted thera...
-
Article
MicroRNAs in body fluids—the mix of hormones and biomarkers
MicroRNAs (miRNAs) is an exciting and fast-moving field in cancer diagnosis and therapeutics. This Review highlights the use of circulating miRNAs in body fluids as a noninvasive diagnostic tool and as a treat...
-
Article
The ROC 'n' role of the multiplex assay for early detection of ovarian cancer
In order to overcome the significant mortality associated with ovarian cancer, a highly sensitive and specific screening test is urgently needed. CA125 is used to assess response to chemotherapy, detect recurr...
-
Article
Angiogenesis as a strategic target for ovarian cancer therapy
Angiogenesis is a complex, highly regulated process that is crucial for tumor growth and metastasis. Insights into the molecular mechanisms of tumor angiogenesis have led to the identification of potential ang...
