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Article
Real-time dispatch optimization for concentrating solar power with thermal energy storage
Concentrating solar power (CSP) plants present a promising path towards utility-scale renewable energy. The power tower, or central receiver, configuration can achieve higher operating temperatures than other ...
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Article
Combining simulation and optimization to derive operating policies for a concentrating solar power plant
Optimizing short-term decisions over a rolling horizon and/or using deterministic penalties to capture system stochasticity can lead to myopic policies that fail to consider unplanned events and their long-ter...
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Article
Open AccessSustainable conversion of biomass to rationally designed lithium-ion battery graphite
The carbon net negative conversion of bio-char, the low value byproduct of pyrolysis bio-oil production from biomass, to high value, very high purity, highly crystalline flake graphite agglomerates with ration...
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Article
Open AccessCombined VEGFR and MAPK pathway inhibition in angiosarcoma
Angiosarcoma is an aggressive malignancy of endothelial cells that carries a high mortality rate. Cytotoxic chemotherapy can elicit clinical responses, but the duration of response is limited. Sequencing revea...
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Article
Open AccessAngiosarcoma heterogeneity and potential therapeutic vulnerability to immune checkpoint blockade: insights from genomic sequencing
Angiosarcoma is an aggressive tumor. Recent case series describe exceptional responses to checkpoint blockade in this disease.
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Article
Dispatch optimization of concentrating solar power with utility-scale photovoltaics
Concentrating solar power (CSP) tower technologies capture thermal radiation from the sun utilizing a field of solar-tracking heliostats. When paired with inexpensive thermal energy storage (TES), CSP technolo...
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Article
Open AccessResponse to PD1 inhibition in conventional chondrosarcoma
Chondrosarcoma is one of the most common malignant bone tumors in adults. Conventional chondrosarcoma represents around 85% of all chondrosarcomas and is notoriously difficult to treat with chemotherapy.
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Article
Open AccessTreatment patterns, efficacy and toxicity of regorafenib in gastrointestinal stromal tumour patients
Regorafenib was approved as third-line therapy for advanced Gastrointestinal Stromal Tumour (GIST) at a starting dose of 160 mg daily 3 weeks on, 1 week off, based on improvement in progression free survival o...
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Article
Open AccessEndothelial cell malignancies: new insights from the laboratory and clinic
Endothelial cell malignancies are rare in the Western world and range from intermediate grade hemangioendothelioma to Kaposi sarcoma to aggressive high-grade angiosarcoma that metastasize early and have a high...
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Article
Open AccessEvaluation of Novel Targeted Therapies in Aggressive Biology Sarcoma Patients after progression from US FDA approved Therapies
Prognosis of patients with advanced sarcoma after progression from FDA approved therapies remains grim. In this study, clinical outcomes of 100 patients with advanced sarcoma who received treatment on novel ta...
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Article
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Ewan Pearson, Kathleen Giacomini and the Metformin Genetics Consortium perform a genome-wide association study for glycemic response to the antidiabetic drug metformin. They find an intronic allele of the GLUT...
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Article
An Unusual Case of Central Retinal Vein Occlusion and Review of the Toxicity Profile of Regorafenib in GIST Patients
Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract with around 5000 new cases per year. Outcomes for patients with GIST dramatically improved after the development o...
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Article
Open AccessA retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments
Limited clinical data on real-world practice patterns are available for patients with metastatic/relapsed soft tissue sarcomas (STS). The primary objective of this study was to evaluate treatment patterns in p...
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Article
A randomized comparison of long-axis and short-axis imaging for in-plane ultrasound-guided popliteal-sciatic perineural catheter insertion
Ultrasound-guided long-axis in-plane sciatic perineural catheter insertion has been described but not validated. For the popliteal-sciatic nerve, we hypothesized that a long-axis in-plane technique, placing t...
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Article
Open AccessErratum to: Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics
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Article
Open AccessPhysical Justification for Negative Remanent Magnetization in Homogeneous Nanoparticles
The phenomenon of negative remanent magnetization (NRM) has been observed experimentally in a number of heterogeneous magnetic systems and has been considered anomalous. The existence of NRM in homogenous magn...
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Article
Open AccessApplication of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics
The goal of this study was to perform candidate gene association with cytotoxicity of chemotherapeutics in cell line models through resequencing and discovery of rare and low frequency variants along with comm...
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Chapter
Electron Transfer Between Cytochrome f and Plastocyanin in Phormidium Laminosum
The reaction between cytochrome f and plastocyanin is central to the photosynthetic electron transport system of all oxygenic organisms. The overall aim of the work described here is to understand how the rate of...
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Article
Solid State Structure and Photoluminescence Properties of Poly(2,5-Dialkoxy-p-Phenyleneethynylene)S
In an effort to better understand the relationship between molecular structure and photophysical properties, we have prepared and investigated a series of novel poly(2, 5-dialkoxy-p-phenyleneethynylene)s. Wide an...
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Article
Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)
Hereditary multiple exostoses is an autosomal dominant disorder that is characterized by short stature and multiple, benign bone tumours. In a majority of families, the genetic defect (EXT1) is linked to the Lang...
