-
Article
Open AccessEnhanced plant-derived vesicles for nucleotide delivery for cancer therapy
Small RNAs (microRNAs [miRNAs] or small interfering RNAs [siRNAs]) are effective tools for cancer therapy, but many of the existing carriers for their delivery are limited by low bioavailability, insufficient ...
-
Article
Open AccessAuthor Correction: Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer
-
Article
Open AccessIn situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy
In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and post-neoadjuvant chemotherapy (NACT) tissues from patients w...
-
Article
Open AccessOvercoming adaptive resistance to anti-VEGF therapy by targeting CD5L
Antiangiogenic treatment targeting the vascular endothelial growth factor (VEGF) pathway is a powerful tool to combat tumor growth and progression; however, drug resistance frequently emerges. We identify CD5L...
-
Article
Open AccessSpatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells
To understand how malignant tumors develop, we tracked cell membrane, nuclear membrane, spindle, and cell cycle dynamics in polyploid giant cancer cells (PGCCs) during the formation of high-grade serous carcin...
-
Article
Open AccessIntegrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors
Low-grade serous ovarian cancer (LGSOC) is a rare disease that occurs more frequently in younger women than those with high-grade disease. The current treatment is suboptimal and a better understanding of the ...
-
Article
Open AccessTargeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex
Poly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated promising clinical activity in multiple cancers. However, resistance to PARP inhibitors remains a substantial clinical challenge. In the present ...
-
Article
Open AccessAuthor Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
-
Article
Open AccessTargeting CCR2+ macrophages with BET inhibitor overcomes adaptive resistance to anti-VEGF therapy in ovarian cancer
Tumor-associated macrophages (TAMs) are known to contribute to adaptive resistance to anti-vascular endothelial growth factor (VEGF) antibody (AVA) therapy in ovarian cancer. BET (bromodomain and extra-termina...
-
Article
Of vascular defense, hemostasis, cancer, and platelet biology: an evolutionary perspective
We have established considerable expertise in studying the role of platelets in cancer biology. From this expertise, we were keen to recognize the numerous venous-, arterial-, microvascular-, and macrovascular...
-
Article
Author Correction: Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
-
Article
Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status
An in-depth analysis of the tumor microenvironment of ovarian cancer is needed. The purpose of this study was to elucidate the architecture of the immune microenvironment of high-grade serous ovarian cancers (...
-
Article
Open AccessAttributions of survival and methods of co** of long-term ovarian cancer survivors: a qualitative study
Only 8–23% of advanced epithelial ovarian cancer patients survive for 10 years or longer. Given the need for targeted interventions to improve survival, we interviewed this relatively rare survivor population ...
-
Article
Open AccessIL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming
To understand the role of polyploid giant cancer cells (PGCCs) in drug resistance and disease relapse, we examined the mRNA expression profile of PGCCs following treatment with paclitaxel in ovarian cancer cel...
-
Article
Open AccessClinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates
Photoacoustic (PA) imaging is a functional and molecular imaging technique capable of high sensitivity and spatiotemporal resolution at depth. Widespread use of PA imaging, however, is limited by currently ava...
-
Article
Author Correction: TP53 loss creates therapeutic vulnerability in colorectal cancer
-
Article
Open AccessCD8+ T cells inhibit metastasis and CXCL4 regulates its function
The mechanism by which immune cells regulate metastasis is unclear. Understanding the role of immune cells in metastasis will guide the development of treatments improving patient survival.
-
Article
Open AccessMitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors
Malignant tumor cells exhibit mitochondrial alterations and are also influenced by biobehavioral processes, but the intersection of biobehavioral factors and mitochondria in malignant tumors remains unexplored...
-
Article
The clinical efficacy and safety of single-agent pembrolizumab in patients with recurrent granulosa cell tumors of the ovary: a case series from a phase II basket trial
Background Treatment of recurrent, unresectable granulosa cell tumor (GCT) of the ovary can be challenging. Given the rarity of the tumor, alternative therapies have been difficult to evaluate in large prospectiv...
-
Article
Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity
Ferroptosis, a form of regulated cell death triggered by lipid peroxidation, was recently identified as an important mechanism in radiotherapy (RT)-mediated tumor suppression and radioresistance, although the ...
