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Article
Open AccessTherapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets
Measles cases have surged pre-COVID-19 and the pandemic has aggravated the problem. Most measles-associated morbidity and mortality arises from destruction of pre-existing immune memory by measles virus (MeV),...
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Article
Open AccessIndividualized microbiotas dictate the impact of dietary fiber on colitis sensitivity
The observation that the intestinal microbiota is central in the development of IBD suggests that dietary fiber, the microbiota’s primary source of nourishment, could play a central role in these diseases. Ac...
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Article
Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity
Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current treatments exclusively target host inflammatory pathways. To understand how host–microbiota interactions become dis...
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Article
Open AccessDirect impact of commonly used dietary emulsifiers on human gut microbiota
Epidemiologic evidence and animal studies implicate dietary emulsifiers in contributing to the increased prevalence of diseases associated with intestinal inflammation, including inflammatory bowel diseases an...
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Article
Open AccessImpact of PepT1 deletion on microbiota composition and colitis requires multiple generations
Numerous studies of knockout mice find impacts on microbiota composition that influence host phenotype. However, such differences can vanish when KO mice are compared directly to WT littermates, suggesting the...
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Article
Open AccessSphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the development of a range of metabolic disorders fro...
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Article
Open AccessErythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
Gut microbiota and their metabolites are instrumental in regulating intestinal homeostasis. However, early-life microbiota associated influences on intestinal development remain incompletely understood. Here w...
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Article
Open AccessFlagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
Alterations in gut microbiota composition are associated with metabolic syndrome and chronic inflammatory diseases such as inflammatory bowel disease. One feature of inflammation-associated gut microbiotas is ...
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Article
Open AccessDietary emulsifiers consumption alters anxiety-like and social-related behaviors in mice in a sex-dependent manner
Dietary emulsifiers carboxylmethylcellulose (CMC) and polysorbate 80 (P80) alter the composition of the intestinal microbiota and induce chronic low-grade inflammation, ultimately leading to metabolic dysregul...
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Article
Publisher Correction: Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition
In Fig. 1d of this Letter, the third group along should have been labelled ‘WT’ rather than ‘Tlr5’. This has been corrected online.
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Article
Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition
Alterations in enteric microbiota are associated with several highly prevalent immune-mediated and metabolic diseases1–3, and experiments involving faecal transplants have indicated that such alterations have a c...
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Article
Open AccessEffects of gut-derived endotoxin on anxiety-like and repetitive behaviors in male and female mice
Gut dysbiosis is observed in several neuropsychiatric disorders exhibiting increases in anxiety behavior, and recent work suggests links between gut inflammation and such disorders. One source of this inflamma...
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Article
Open AccessExposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study
Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are l...
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Correction: Corrigendum: Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Nature 519, 92–96 (2015); doi:10.1038/nature14232 Some clarifications are provided to this Letter; these do not alter any of the central conclusions but, rather, are provided in the interests of transparency a...
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Article
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Emulsifying agents, which are common food additives in the human diet, induce low-grade inflammation and obesity/metabolic syndrome in mice, suggesting that further investigation into the potential impact of d...
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Article
Toward understanding and manipulating the gut microbiota
New techniques have introduced unprecedented sensitivity to the investigation of the gut microbiota, enabling insights into the discrete contributions of select bacterial species and advancing our mechanistic ...
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Article
Open AccessLoss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice
Toll-like receptor-4 (TLR4) triggers inflammatory signaling in response to microbial lipoploysaccharide. It has been reported that loss of TLR4 protected against saturated fat-induced inflammation and insulin ...
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Article
Toll like receptor-5: protecting the gut from enteric microbes
The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in ide...
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Article
Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice
The extreme susceptibility to infection with Salmonella Typhimurium of wild-derived MOLF/Ei mice has been linked to one genomic region on Chromosome 1 (Ity3). A member of the Toll-like receptors family, Tlr5, loc...
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Article
Intestinal epithelial cell regulation of mucosal inflammation
The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients whil...
