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Article
CTLA-4 tail fusion enhances CAR-T antitumor immunity
Chimeric antigen receptor (CAR)-T cells are powerful therapeutics; however, their efficacy is often hindered by critical hurdles. Here utilizing the endocytic feature of the cytotoxic T-lymphocyte-associated a...
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Article
Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens
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Article
Open AccessMultiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation
Single-cell assays have enriched our understanding of hematopoiesis and, more generally, stem and progenitor cell biology. However, these single-end-point approaches provide only a static snapshot of the state...
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Article
Open AccessComputation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome
Single-cell RNA-sequencing data has revolutionized our ability to understand of the patterns of cell–cell and ligand–receptor connectivity that influence the function of tissues and organs. However, the quanti...
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Article
Author Correction: Evolution of placental invasion and cancer metastasis are causally linked
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Evolution of placental invasion and cancer metastasis are causally linked
Among mammals, placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (for example, humans) are more vulnerable to malignancy. To explain this correlation, w...
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Article
A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm
In asthma, the contraction of the airway smooth muscle and the subsequent decrease in airflow involve a poorly understood set of mechanical and biochemical events. Organ-level and molecular-scale models of the...
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Article
Open AccessSwitch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases
Collective cell migration occurs in many patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding epithelial sheets depends on extracellular cues, includin...
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Article
Open AccessSelf-induced mechanical stress can trigger biofilm formation in uropathogenic Escherichia coli
Bacterial biofilms represent an important medical problem; however, the mechanisms of the onset of biofilm formation are poorly understood. Here, using new controlled methods allowing high-throughput and repro...
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Article
Open AccessBiomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread
The root cause of cancer mortality and morbidity is the metastatic spread of the primary tumor, but underlying mechanisms remain elusive. Here we investigate biomechanical interactions that may accompany invas...
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Article
Directed migration of cancer cells guided by the graded texture of the underlying matrix
Living cells and the extracellular matrix (ECM) can exhibit complex interactions that define key developmental, physiological and pathological processes. Here, we report a new type of directed migration—which ...
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Article
Mechanics of Microenvironment as Instructive Cues Guiding Stem Cell Behavior
Stem cells reside in a complex milieu during development, or in adult tissues, as well as in culture conditions. Their decision to differentiate, self-renew, or migrate is a result of an integrated response to...
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Article
Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration
Directed cell migration in native environments is influenced by multiple migratory cues. These cues may include simultaneously occurring attractive soluble growth factor gradients and repulsive effects arising...
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Article
Modeling Intercellular Transfer of Biomolecules Through Tunneling Nanotubes
Tunneling nanotubes (TNTs) have previosly been observed as long and thin transient structures forming between cells and intercellular protein transfer through them has been experimentally verified. It is hypot...
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Article
Chemically inducible diffusion trap at cilia reveals molecular sieve–like barrier
Chemically inducible diffusion trap at cilia (CIDTc), a method to trap proteins in the cilia, was applied to study the kinetics of protein accumulation and reveal a molecular sieve at the ciliary base. CIDTc c...
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Chapter and Conference Paper
Stem Cell Differentiation as a Renewal-Reward Process: Predictions and Validation in the Colonic Crypt
Stem cells serve as persistent reservoirs for replenishment of rapidly renewing tissues, frequently also ensuring that the correct tissue morphology is maintained. This process is inherently stochastic due to ...
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Article
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit
PKA initiates and modulates the frequency of oscillations of Ca2+ and cAMP in insulin-secreting cells and itself oscillates to provide spatiotemporal control of downstream signals on the basis of diverse inputs. ...
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Chapter
Using Lab-on-a-Chip Technologies for Stem Cell Biology
The introduction of microtechnology and microfluidic platforms for cell culture can dramatically enhance the pace of stem cell research. With the use of microfluidic-based techniques, extracellular microenviro...
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Article
Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires
Precise delivery of molecular doses of biologically active chemicals to a pre-specified single cell among many, or a specific subcellular location, is still a largely unmet challenge hampering our understandin...
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Chapter and Conference Paper
A Scalable and Integrative System for Pathway Bioinformatics and Systems Biology
Motivation: Progress in systems biology depends on develo** scalable informatics tools to predictively model, visualize, and flexibly store information about complex biological systems. Scalability of these ...
