15 Result(s)

Article

Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Peter Pickkers, Derek C. Angus, Kristie Bass, Rinaldo Bellomo… in Intensive Care Medicine (2024)

Article

Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidn...

Peter Pickkers, Derek C. Angus, Kristie Bass, Rinaldo Bellomo… in Intensive Care Medicine (2024)

Article

The effect of recombinant erythropoietin on long-term outcome after moderate-to-severe traumatic brain injury

Recombinant erythropoietin (EPO) administered for traumatic brain injury (TBI) may increase short-term survival, but the long-term effect is unknown.

Markus B. Skrifvars, Nora Luethi, Michael Bailey, Craig French… in Intensive Care Medicine (2023)

Article

Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO₂) and the episodes of hypoxem...

Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball… in Critical Care (2022)

Article

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (...

Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Laura Merson… in Critical Care (2022)

Article

Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial

The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of ...

Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball… in Intensive Care Medicine (2022)

Article

Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis

The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patie...

Gianluigi Li Bassi, Kristen Gibbons, Jacky Y. Suen, Heidi J. Dalton… in Critical Care (2022)

Article

An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

Heterogeneous respiratory system static compliance (C_RS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous small-...

Gianluigi Li Bassi, Jacky Y. Suen, Heidi J. Dalton, Nicole White… in Critical Care (2021)

Article

Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study

Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood.

Tomoko Fujii, Andrew A. Udy, Alistair Nichol, Rinaldo Bellomo… in Critical Care (2021)

Article

Emerging pharmacological therapies for ARDS: COVID-19 and beyond

ARDS, first described in 1967, is the commonest form of acute severe hypoxemic respiratory failure. Despite considerable advances in our knowledge regarding the pathophysiology of ARDS, insights into the biolo...

Shahd Horie, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham… in Intensive Care Medicine (2020)

Article

Targeted therapeutic mild hypercapnia after cardiac arrest

Glenn M. Eastwood, Alistair Nichol, Matt P. Wise in Critical Care (2017)

Article

Age of red blood cells and transfusion in critically ill patients

Red blood cells (RBC) storage facilitates the supply of RBC to meet the clinical demand for transfusion and to avoid wastage. However, RBC storage is associated with adverse changes in erythrocytes and their p...

Cécile Aubron, Alistair Nichol, D Jamie Cooper, Rinaldo Bellomo in Annals of Intensive Care (2013)

Article

Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia

The purpose of the study was to assess the long term outcome and quality of life of patients with acute respiratory distress syndrome (ARDS) receiving extracorporeal membrane oxygenation (ECMO) for refractory ...

Carol L Hodgson, Kate Hayes, Tori Everard, Alistair Nichol… in Critical Care (2012)

Article

Dynamic lactate indices as predictors of outcome in critically ill patients

Dynamic changes in lactate concentrations in the critically ill may predict patient outcome more accurately than static indices. We aimed to compare the predictive value of dynamic indices of lactatemia in the...

Alistair Nichol, Michael Bailey, Moritoki Egi, Ville Pettila, Craig French… in Critical Care (2011)

Article

Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest

Hyperoxia has recently been reported as an independent risk factor for mortality in patients resuscitated from cardiac arrest. We examined the independent relationship between hyperoxia and outcomes in such pa...

Rinaldo Bellomo, Michael Bailey, Glenn M Eastwood, Alistair Nichol… in Critical Care (2011)