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Open AccessPerfusion deficits may underlie lung and kidney injury in severe COVID-19 disease: insights from a multicenter international cohort study
Lung perfusion defects, mainly due to endothelial and coagulation activation, are a key contributor to COVID-19 respiratory failure. COVID-19 patients may also develop acute kidney injury (AKI) because of rena...
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Article
Open AccessThe CHARTER-Ireland trial: can nebulised heparin reduce acute lung injury in patients with SARS-CoV-2 requiring advanced respiratory support in Ireland: a study protocol and statistical analysis plan for a randomised control trial
COVID-19 pneumonia is associated with the development of acute respiratory distress syndrome (ARDS) displaying some typical histological features. These include diffuse alveolar damage with extensive pulmonary...
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Article
Open AccessFactors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial
Awake prone positioning (APP) improves oxygenation in coronavirus disease (COVID-19) patients and, when successful, may decrease the risk of intubation. However, factors associated with APP success remain unkn...
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Article
Open AccessSentiment analysis of user feedback on the HSE’s Covid-19 contact tracing app
Digital Contact Tracing is seen as a key tool in reducing the propagation of Covid-19. But it requires high uptake and continued participation across the population to be effective. To achieve sufficient uptak...
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Acute Hypoxaemic Respiratory Failure and Acute Respiratory Distress Syndrome
Acute hypoxaemic respiratory failure (AHRF) constitutes a group of conditions characterized by the acute onset of severe hypoxaemia, increased respiratory work, leading to respiratory failure. AHRF causes rang...
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Article
A national survey of attitudes to COVID-19 digital contact tracing in the Republic of Ireland
Contact tracing remains a critical part of controlling COVID-19 spread. Many countries have developed novel software applications (Apps) in an effort to augment traditional contact tracing methods.
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Article
Open AccessDeath in hospital following ICU discharge: insights from the LUNG SAFE study
To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.
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Open AccessProne positioning improves oxygenation and lung recruitment in patients with SARS-CoV-2 acute respiratory distress syndrome; a single centre cohort study of 20 consecutive patients
We aimed to characterize the effects of prone positioning on respiratory mechanics and oxygenation in invasively ventilated patients with SARS-CoV-2 ARDS.
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Article
Emerging pharmacological therapies for ARDS: COVID-19 and beyond
ARDS, first described in 1967, is the commonest form of acute severe hypoxemic respiratory failure. Despite considerable advances in our knowledge regarding the pathophysiology of ARDS, insights into the biolo...
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Article
Open AccessHyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study
Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observa...
