39 Result(s)

Article

Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest: a prospective multicentre study

Application of standardised and automated assessments of head computed tomography (CT) for neuroprognostication after out-of-hospital cardiac arrest.

Margareta Lang, Martin Kenda, Michael Scheel, Juha Martola… in Intensive Care Medicine (2024)

Article

Mechanical ventilation variables associated with high pulmonary artery pressures in ARDS patients: a post hoc analysis

The relationship between indices of mechanical ventilation and pulmonary artery pressures remains ill-defined in ARDS. As our understanding of mechanical ventilation has progressed, there is now a greater appr...

Joseph R. Riddell, Benjamin J. Jones, Bruno M. Fernandes, Daniel J. Law… in Critical Care (2022)

Article

Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when...

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis… in Critical Care (2022)

Article

Interleukin-6 as a prognostic biomarker of clinical outcomes after traumatic brain injury: a systematic review

Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. There are currently no early biomarkers for prognosis in routine clinical use. Interleukin-6 (IL-6) is a potential biomarker ...

Setthasorn Zhi Yang Ooi, Robert James Spencer, Megan Hodgson… in Neurosurgical Review (2022)

Article

Influence of temperature management at 33 °C versus normothermia on survival in patients with vasopressor support after out-of-hospital cardiac arrest: a post hoc analysis of the TTM-2 trial

Targeted temperature management at 33 °C (TTM33) has been employed in effort to mitigate brain injury in unconscious survivors of out-of-hospital cardiac arrest (OHCA). Current guidelines recommend prevention ...

Joachim Düring, Martin Annborn, Alain Cariou, Michelle S. Chew… in Critical Care (2022)

Article

Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest

The majority of unconscious patients after cardiac arrest (CA) do not fulfill guideline criteria for a likely poor outcome, their prognosis is considered “indeterminate”. We compared brain injury markers in bl...

Marion Moseby-Knappe, Niklas Mattsson-Carlgren, Pascal Stammet… in Intensive Care Medicine (2021)

Article

Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial

To quantify potential heterogeneity of treatment effect (HTE), of early sedation with dexmedetomidine (DEX) compared with usual care, and identify patients who have a high probability of lower or higher 90-day...

Yahya Shehabi, Ary Serpa Neto, Belinda D. Howe, Rinaldo Bellomo… in Intensive Care Medicine (2021)

Article

Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm

Prognostication of neurological outcome in patients who remain comatose after cardiac arrest resuscitation is complex. Clinical variables, as well as biomarkers of brain injury, cardiac injury, and systemic in...

Peder Andersson, Jesper Johnsson, Ola Björnsson, Tobias Cronberg… in Critical Care (2021)

Article

Pantoprazole prophylaxis in ICU patients with high severity of disease: a post hoc analysis of the placebo-controlled SUP-ICU trial

In the subgroup of patients with Simplified Acute Physiology Score (SAPS) II > 53 in the Stress Ulcer Prophylaxis in Intensive Care Unit (SUP-ICU) trial, there was interaction (P = 0.049) suggesting increased mor...

Søren Marker, Anders Perner, Jørn Wetterslev, Mette Krag… in Intensive Care Medicine (2019)

Article

Associations between partial pressure of oxygen and neurological outcome in out-of-hospital cardiac arrest patients: an explorative analysis of a randomized trial

Exposure to hyperoxemia and hypoxemia is common in out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation (ROSC), but its effects on neurological outcome are uncertain, and ...

Florian Ebner, Susann Ullén, Anders Åneman, Tobias Cronberg… in Critical Care (2019)

Article

Carbon dioxide dynamics in relation to neurological outcome in resuscitated out-of-hospital cardiac arrest patients: an exploratory Target Temperature Management Trial substudy

Dyscarbia is common in out-of-hospital cardiac arrest (OHCA) patients and its association to neurological outcome is undetermined.

Florian Ebner, Matt B. A. Harmon, Anders Aneman, Tobias Cronberg… in Critical Care (2018)

Article

Effects of stress ulcer prophylaxis in adult ICU patients receiving renal replacement therapy (Sup-Icu RENal, SIREN): Study protocol for a pre-planned observational study

Proton pump inhibitors are often used in critically ill patients to prevent gastrointestinal bleeding despite limited evidence for benefit. Patients with acute kidney injury requiring renal replacement therapy...

Joerg C. Schefold, Anders Perner, Theis Lange, Jørn Wetterslev, Matt P. Wise… in Trials (2018)

Article

Targeted therapeutic mild hypercapnia after cardiac arrest

Glenn M. Eastwood, Alistair Nichol, Matt P. Wise in Critical Care (2017)

Article

Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C

We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and the potential influence of two target temperatures (33 °C and 36 °C) on serum ...

Pascal Stammet, Josef Dankiewicz, Niklas Nielsen, François Fays… in Critical Care (2017)

Article

Early predictors of poor outcome after out-of-hospital cardiac arrest

Early identification of predictors for a poor long-term outcome in patients who survive the initial phase of out-of-hospital cardiac arrest (OHCA) may facilitate future clinical research, the process of care a...

Louise Martinell, Niklas Nielsen, Johan Herlitz, Thomas Karlsson… in Critical Care (2017)

Article

Endotracheal tubes and fluid aspiration: an in vitro evaluation of new cuff technologies

Aspiration of subglottic secretions past the endotracheal tube (ETT) cuff is a prerequisite for develo** ventilator-associated pneumonia (VAP). Subglottic secretion drainage (SSD) ETTs reduce aspiration of s...

Maryanne Z. Mariyaselvam, Lucy L. Marsh, Sarah Bamford, Ann Smith… in BMC Anesthesiology (2017)

Article

Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial

Critically ill patients in the intensive care unit (ICU) are at risk of clinically important gastrointestinal bleeding, and acid suppressants are frequently used prophylactically. However, stress ulcer prophyl...

Mette Krag, Anders Perner, Jørn Wetterslev, Matt P. Wise, Mark Borthwick… in Trials (2016)

Article

Passive leg raising and compression stockings: a note of caution

Cyril Jacob Chacko, Matt P Wise, Paul J Frost in Critical Care (2015)