36 Result(s)

Article

Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Peter Pickkers, Derek C. Angus, Kristie Bass, Rinaldo Bellomo… in Intensive Care Medicine (2024)

Article

Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud… in Nature Communications (2024)

Article

Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidn...

Peter Pickkers, Derek C. Angus, Kristie Bass, Rinaldo Bellomo… in Intensive Care Medicine (2024)

Article

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu… in Nature (2023)

Article

The effect of recombinant erythropoietin on long-term outcome after moderate-to-severe traumatic brain injury

Recombinant erythropoietin (EPO) administered for traumatic brain injury (TBI) may increase short-term survival, but the long-term effect is unknown.

Markus B. Skrifvars, Nora Luethi, Michael Bailey, Craig French… in Intensive Care Medicine (2023)

Article

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown¹ to be highly efficient for discovery of genetic associations². Despite the advanced stage of ...

Erola Pairo-Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu… in Nature (2023)

Article

Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO₂) and the episodes of hypoxem...

Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball… in Critical Care (2022)

Article

Comparative effectiveness of neutralising monoclonal antibodies in high risk COVID-19 patients: a Bayesian network meta-analysis

The purpose of this work was to review and synthesise the evidence on the comparative effectiveness of neutralising monoclonal antibody (nMAB) therapies in individuals exposed to or infected with SARS-CoV-2 an...

David McConnell, Marie Harte, Cathal Walsh, Desmond Murphy… in Scientific Reports (2022)

Article

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (...

Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Laura Merson… in Critical Care (2022)

Article

Correction: Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups—practical guidance to support better practice

Shoba Dawson, Katie Banister, Katie Biggs, Seonaidh Cotton, Declan Devane… in Trials (2022)

Article

Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups—practical guidance to support better practice

Randomised trials, especially those intended to directly inform clinical practice and policy, should be designed to reflect all those who could benefit from the intervention under test should it prove effectiv...

Shoba Dawson, Katie Banister, Katie Biggs, Seonaidh Cotton, Declan Devane… in Trials (2022)

Article

Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial

The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of ...

Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball… in Intensive Care Medicine (2022)

Article

Correction: Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analyses

Pepa Bruce, Kate Ainscough, Lee Hatter, Irene Braithwaite, Lindsay R. Berry… in Trials (2022)

Article

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care¹ or hospitalization^2–4 after infection with SARS-CoV-2...

Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Alex Stuckey… in Nature (2022)

Article

Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analyses

Coronavirus disease 2019 (COVID-19) has exposed the disproportionate effects of pandemics on frontline workers and the ethical imperative to provide effective prophylaxis. We present a model for a pragmatic ra...

Pepa Bruce, Kate Ainscough, Lee Hatter, Irene Braithwaite, Lindsay R. Berry… in Trials (2022)

Article

Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis

The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patie...

Gianluigi Li Bassi, Kristen Gibbons, Jacky Y. Suen, Heidi J. Dalton… in Critical Care (2022)

Article

Normalising comparative effectiveness trials as clinical practice

There is a lack of high-quality evidence underpinning many contemporary clinical practice guidelines embedded in the healthcare systems, leading to treatment uncertainty and practice variation in most medical ...

Tom Briffa, Tanya Symons, Nikolajs Zeps, Nicola Straiton… in Trials (2021)

Article

An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

Heterogeneous respiratory system static compliance (C_RS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous small-...

Gianluigi Li Bassi, Jacky Y. Suen, Heidi J. Dalton, Nicole White… in Critical Care (2021)

Article

Preparing accessible and understandable clinical research participant information leaflets and consent forms: a set of guidelines from an expert consensus conference

In line with Good Clinical Practice and the Declaration of Helsinki, it is the investigator’s responsibility to ensure that research participants are sufficiently informed, to enable the provision of informed ...

Eleanor Coleman, Lydia O’Sullivan, Rachel Crowley… in Research Involvement and Engagement (2021)

Article

Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud… in Nature Communications (2021)