13 Result(s)
within
Alberto Mantovani
Medicine & Public Health
Immunology
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Chapter
Adoptive T-Cell Therapy: Optimizing Chemokine Receptor-Mediated Homing of T-Cells in Cancer Immunotherapy
Immunotherapy based on adoptive T-cell transfer provides a promising form of cancer therapy, but often fails to induce long-lasting responses in the great majority of patients. During the past few decades, sev...
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Chapter
Tumor-Associated Myeloid Cells in Cancer Progression
The tumor microenvironment plays a pivotal role in orchestrating tumor initiation, progression, and spreading, as well as response to therapy. Myeloid immune cells infiltrating tumors are integral component of...
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Article
Open AccessThe great debate at “Immunotherapy Bridge 2018”, Naples, November 29th, 2018
As part of the 2018 Immunotherapy Bridge congress (November 28–29, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on four topical clinical issues in immunotherapy tod...
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Chapter
Microenvironment and Immunology of the Human Pleural Malignant Mesothelioma
Human malignant pleural mesothelioma (MPM) is strongly related to pre-existing and long-lasting conditions of chronic inflammation and tissue injury, caused by the inhalation of airborne asbestos fibers. The l...
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Article
PTX3, Anti-PTX3, and Anti-C1q Autoantibodies in Lupus Glomerulonephritis
Pentraxin 3 (PTX3) is an acute-phase protein involved in C1q clearance. The presence of anti-C1q and the absence of anti-PTX3 antibodies were associated with lupus glomerulonephritis (LGLN). Our aim was to ass...
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Article
Open AccessCombined low-FOXP3+ and -CD3+tumor infiltrating lymphocytes: a signature of stage II MSS colorectal cancer at high-risk of recurrence
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Article
Expression and modulation of a mononuclear phagocyte differentiation antigen (PAM-1) during in vitro maturation of peripheral blood monocytes
Human macrophages obtained by in vitro maturation of peripheral blood monocytes express a surface antigen, PAM-1, recognized by a monoclonal antibody and typical of pulmonary alveolar and tissue macrophages. P...
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Article
Recent developments in the cell biology of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: activities on endothelial cells
Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor were considered as growth and differentiation factors restricted to hematopoietic cells. It was recently found that no...
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Chapter
Biological Significance and Therapeutic Potential of Tumor-Associated Leukocytes
Macrophages are a major component of the lymphoreticular infiltrate of rodent and human tumors (Mantovani et al 1992a). Since these cells are situated at the very interface between tumor and host, they may rep...
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Article
Detection of a transcriptional block in the first intron of the human c-myb gene
The levels of expression of the murine c-myb gene, like those of several other proto-oncogenes, can be controlled by a block of transcriptional elongation within the first intron of the gene. We have performed ru...
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Article
DR antigen expression on ovarian carcinoma cells does not correlate with their capacity to elicit an autologous proliferative response
Expression of HLA-DR antigens by purified preparations of human ovarian carcinoma cells freshly isolated from surgical specimens was examined in parallel with the capacity of tumor cells to elicit a blastogeni...
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Article
Proliferative response of lymphocytes from ovarian cancer patients to autologous tumor cells
Peripheral blood lymphocytes (PBL) from 43 patients with histologically confirmed ovarian carcinoma were stimulated in mixed lymphocyte-tumor culture (MLTC) with purified autologous tumor cells. Positive resul...
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Article
Immunological and genotypic analysis of human Tγ-lymphoproliferative disorders
Tγ-lymphoproliferative disorders (Tγ-LPD) are rare diseases characterized by expansion of circulating elements with resemblance to large granular lymphocytes (LGL). We have studied 12 patients with Tγ-LPD.Morphol...
