-
Article
MRIO: the Magnetic Resonance Imaging Acquisition and Analysis Ontology
Magnetic resonance imaging of the brain is a useful tool in both the clinic and research settings, aiding in the diagnosis and treatments of neurological disease and expanding our knowledge of the brain. Howev...
-
Article
Open AccessStructuring, reuse and analysis of electronic dental data using the Oral Health and Disease Ontology
A key challenge for improving the quality of health care is to be able to use a common framework to work with patient information acquired in any of the health and life science disciplines. Patient information...
-
Article
Open AccessThe Cell Ontology 2016: enhanced content, modularization, and ontology interoperability
The Cell Ontology (CL) is an OBO Foundry candidate ontology covering the domain of canonical, natural biological cell types. Since its inception in 2005, the CL has undergone multiple rounds of revision and ex...
-
Article
Open AccessOmniSearch: a semantic search system based on the Ontology for MIcroRNA Target (OMIT) for microRNA-target gene interaction data
As a special class of non-coding RNAs (ncRNAs), microRNAs (miRNAs) perform important roles in numerous biological and pathological processes. The realization of miRNA functions depends largely on how miRNAs re...
-
Article
Open AccessThe Non-Coding RNA Ontology (NCRO): a comprehensive resource for the unification of non-coding RNA biology
In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identificat...
-
Article
Open AccessThe neurological disease ontology
We are develo** the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representati...
-
Article
Open AccessThe representation of protein complexes in the Protein Ontology (PRO)
Representing species-specific proteins and protein complexes in ontologies that are both human- and machine-readable facilitates the retrieval, analysis, and interpretation of genome-scale data sets. Although ...
-
Article
Open AccessMeeting Report: BioSharing at ISMB 2010
This report summarizes the proceedings of the one day BioSharing meeting held at the Intelligent Systems for Molecular Biology (ISMB) 2010 conference in Boston, MA, USA This inaugural BioSharing event was host...
-
Article
Open AccessModeling biomedical experimental processes with OBI
Experimental descriptions are typically stored as free text without using standardized terminology, creating challenges in comparison, reproduction and analysis. These difficulties impose limitations on data e...
-
Article
Open AccessOntoFox: web-based support for ontology reuse
Ontology development is a rapidly growing area of research, especially in the life sciences domain. To promote collaboration and interoperability between different projects, the OBO Foundry principles require ...
-
Chapter and Conference Paper
Simplifying Access to Large-Scale Health Care and Life Sciences Datasets
Within the health care and life sciences (HCLS) domain, a plethora of phenomena exists that range across the whole “vertical scale” of biomedicine. To accurately research and describe those phenomena, a tremen...
-
Article
The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration
The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data usin...
-
Article
Open AccessAdvancing translational research with the Semantic Web
A fundamental goal of the U.S. National Institute of Health (NIH) "Roadmap" is to strengthen Translational Research, defined as the movement of discoveries in basic research to application at the clinical level. ...
-
Chapter and Conference Paper
Connectedness Profiles in Protein Networks for the Analysis of Gene Expression Data
Knowledge about protein function is often encoded in the form of large and sparse undirected graphs where vertices are proteins and edges represent their functional relationships. One elementary task in the co...