18 Result(s)

Article

Biodistribution and dosimetry in human healthy volunteers of the PET radioligands [¹¹C]CHDI-00485180-R and [¹¹C]CHDI-00485626, designed for quantification of cerebral aggregated mutant huntingtin

Huntington’s disease is caused by a trinucleotide expansion in the HTT gene, which leads to aggregation of mutant huntingtin (mHTT) protein in the brain and neurotoxicity. Direct in vivo measurement of mHTT aggre...

Aline Delva, Michel Koole, Kim Serdons… in European Journal of Nuclear Medicine and M… (2022)

Article

Reactivation of super-enhancers by KLF4 in human Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) is a disease of significant morbidity and mortality and rarely diagnosed in early stages. Despite extensive genetic and genomic characterization, targeted therapeu...

Maria Tsompana, Christian Gluck, Isha Sethi, Ishita Joshi, Jonathan Bard… in Oncogene (2020)

Article

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since...

Bryan Zeitler, Steven Froelich, Kimberly Marlen, David A Shivak, Qi Yu… in Nature Medicine (2019)

Chapter

XSPAN — A Cross-Species Anatomy Network

XSPAN¹, a cross-species anatomy network, is a web-based service that aims to provide a user with information linking tissues in the anatomical ontologies of the main model species. XSPAN incorporates a database t...

Albert Burger, Jonathan Bard in Anatomy Ontologies for Bioinformatics (2008)

Chapter

Anatomical Ontologies for Model Organisms: The Fungi and Animals

This chapter reviews how the richness of animal and fungal anatomy can be incorporated into formal ontologies so that knowledge of tissue organisation can be made accessible both to biologists and to other com...

Jonathan Bard in Anatomy Ontologies for Bioinformatics (2008)

Article

The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration

The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data usin...

Barry Smith, Michael Ashburner, Cornelius Rosse, Jonathan Bard… in Nature Biotechnology (2007)

Article

Engineering Optimization: Theory and Practice, Third Edition

Jonathan Bard in IIE Transactions (1997)

Article

Mathematical Programming for Industrial Engineers

Jonathan Bard in IIE Transactions (1997)

Article

Start at the beginning

Zygote: The Biology of Gametes and Early Embryos.

Jonathan Bard in Nature (1994)

Article

The candidate Wilms' tumour gene is involved in genitourinary development

WILMS' tumour is an embryonic kidney tumour thought to arise through aberrant mesenchymal stem cell differentiation¹ and to result from loss of function of a 'tumour suppressor' gene(s)². Both sporadic and syndro...

Kathryn Pritchard-Jones, Stewart Fleming, Duncan Davidson, Wendy Bickmore… in Nature (1990)

Article

Cellular Interactions in Mass Cultures of Human Diploid Fibroblasts

Fibroblasts in mass cultures generate self-maintaining parallel arrays. In the presence of accumulated collagen, arrays migrate over one another to build meta-stable orthogonal multilayers. The cell partaking ...

TOM ELSDALE, JONATHAN BARD in Nature (1972)