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Article
Exploring pharmacokinetics and herb-drug interactions of an herbal extract mixture derived from Poria cocos and Morus alba L.
Poria cocos and Morus alba L., recognized as traditional Chinese medicines (TCMs), have gained attention for their diverse pharmacological effects. An herbal extract mixture (named as NB-02) combining these two b...
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Article
Open AccessAβ-induced vulnerability propagates via the brain’s default mode network
The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission tomography ([18F]florbetapir tracer for Aβ and [18F]FDG t...
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Article
Open AccessIdentification of five novel genetic loci related to facial morphology by genome-wide association studies
Face morphology is strongly determined by genetic factors. However, only a small number of genes related to face morphology have been identified to date. Here, we performed a two-stage genome-wide association ...
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Article
Open AccessAmyloid and tau signatures of brain metabolic decline in preclinical Alzheimer’s disease
We aimed to determine the amyloid (Aβ) and tau biomarker levels associated with imminent Alzheimer’s disease (AD) - related metabolic decline in cognitively normal individuals.
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Article
Open AccessEffects of cold sensitivity in the extremities on circulating adiponectin levels and metabolic syndrome in women
In adipose tissues, adipokine levels, including adiponectin and leptin, are involved in insulin sensitivity and are reciprocally induced by cold temperature stress. Thermogenic response in the extremities (han...
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Article
Open AccessThe obesity-risk variant of FTO is inversely related with the So-Eum constitutional type: genome-wide association and replication analyses
Body constitutional types described in the traditional Korean medicine system, Sasang constitutional medicine, are heritable, as has been revealed by twin and family studies. Thus, individuals with the same co...
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Article
Open AccessGenetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans
Abnormal lipid concentrations are risk factors for atherosclerosis and cardiovascular disease. The pathological susceptibility to cardiovascular disease risks such as metabolic syndrome, diabetes mellitus, hyp...
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Article
Open AccessEffects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans
Single-nucleotide polymorphisms (SNPs) around the apolipoprotein A5 gene (APOA5) have pleiotropic effects on the levels of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C). APOA5 SNPs have also ...
