-
Article
Open AccessThe age distribution of facial metrics in two large Korean populations
Growth and alterations in craniofacial morphology have attracted interest in many fields of science, especially physical anthropology, genetics and forensic sciences. We performed an analysis of craniofacial m...
-
Article
Open AccessIdentification of five novel genetic loci related to facial morphology by genome-wide association studies
Face morphology is strongly determined by genetic factors. However, only a small number of genes related to face morphology have been identified to date. Here, we performed a two-stage genome-wide association ...
-
Article
Whole-body cold tolerance in older Korean female divers “haenyeo” during cold air exposure: effects of repetitive cold exposure and aging
This study was conducted to investigate the effects of chronic and repetitive diving in cold sea water on physiological responses to cold in older Korean female divers, Haenyeo, who have been exposed to cold w...
-
Article
Finger cold-induced vasodilation of older Korean female divers, haenyeo: effects of chronic cold exposure and aging
The aim of the present study was to evaluate the local cold tolerance of older Korean female divers, haenyeo (N = 22) in terms of cold acclimatization and ageing. As control groups, older non-diving females (N = ...
-
Article
Open AccessEffects of cold sensitivity in the extremities on circulating adiponectin levels and metabolic syndrome in women
In adipose tissues, adipokine levels, including adiponectin and leptin, are involved in insulin sensitivity and are reciprocally induced by cold temperature stress. Thermogenic response in the extremities (han...
-
Article
Open AccessThe obesity-risk variant of FTO is inversely related with the So-Eum constitutional type: genome-wide association and replication analyses
Body constitutional types described in the traditional Korean medicine system, Sasang constitutional medicine, are heritable, as has been revealed by twin and family studies. Thus, individuals with the same co...
-
Article
Open AccessGenetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans
Abnormal lipid concentrations are risk factors for atherosclerosis and cardiovascular disease. The pathological susceptibility to cardiovascular disease risks such as metabolic syndrome, diabetes mellitus, hyp...
-
Article
Open AccessEffects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans
Single-nucleotide polymorphisms (SNPs) around the apolipoprotein A5 gene (APOA5) have pleiotropic effects on the levels of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C). APOA5 SNPs have also ...
-
Article
Open AccessAssociation analyses of the INSIG2polymorphism in the obesity and cholesterol levels of Korean populations
While INSIG2 has been reported to be associated with BMI in many populations, conflicting results have prevented consensus over its role. In analyses of mice and cell cultures the gene has been found to be involv...