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Open AccessLipid-coated mesoporous silica nanoparticles for anti-viral applications via delivery of CRISPR-Cas9 ribonucleoproteins
Emerging and re-emerging viral pathogens present a unique challenge for anti-viral therapeutic development. Anti-viral approaches with high flexibility and rapid production times are essential for combating th...
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Open AccessCTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells
Impaired autophagy, a cellular digestion process that eliminates proteins and damaged organelles, has been implicated in neurodegenerative diseases, including motor neuron disorders. Motor neuron targeted upre...
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Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns
The production of personalized cancer vaccines made from autologous tumour cells could benefit from mechanisms that enhance immunogenicity. Here we show that cancer vaccines can be made via the cryogenic silic...
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Chapter
Emerging Lipid-Coated Silica Nanoparticles for Cancer Therapy
Siliceous nanomaterials are attractive candidates for applications in cancer theranostics due to their precise synthesis control, ease of surface functionalization, accuracy of characterization, controllable r...
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Chapter
Nanoparticle Vaccines for Immunotherapy: From Design to Clinical Trials
Nanoparticles have the capacity to activate the immune system, based on both intrinsic particle characteristics and through the delivery of immune activating cargo. Co-delivery of antigens with adjuvants, such...
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Engineering of large-pore lipid-coated mesoporous silica nanoparticles for dual cargo delivery to cancer cells
Lipid-coated mesoporous silica nanoparticles (LC-MSNs) have recently emerged as a next-generation cargo delivery nanosystem combining the unique attributes of both the organic and inorganic components. The hig...
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Open AccessEstablishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics
The progress of nanoparticle (NP)-based drug delivery has been hindered by an inability to establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled, mesoporous silica nan...
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Open AccessLipid-Coated Mesoporous Silica Nanoparticles for the Delivery of the ML336 Antiviral to Inhibit Encephalitic Alphavirus Infection
Venezuelan equine encephalitis virus (VEEV) poses a major public health risk due to its amenability for use as a bioterrorism agent and its severe health consequences in humans. ML336 is a recently developed c...
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Reference Work Entry In depth
Click Functionalization of Sol-Gel Materials
The design of complex, multifunctional, and versatile materials for diverse applications ranging from nanomedicine to catalysis requires simple and reliable functionalization methodologies. Click chemistry des...
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Living Reference Work Entry In depth
Click Functionalization of Sol–Gel Materials
The design of complex, multifunctional, and versatile materials for diverse applications ranging from nanomedicine to catalysis requires simple and reliable functionalization methodologies. Click chemistry des...
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Article
Click approaches in sol–gel chemistry
The combination of the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction with sol–gel processing enables the versatile preparation of sol–gel materials under different shapes with targeted functiona...
