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Article
Open AccessDopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo
The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndr...
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Article
Open AccessGenome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal le...
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Article
Genetic architecture of subcortical brain structures in 38,851 individuals
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate n...
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Chapter and Conference Paper
Bridging Imaging, Genetics, and Diagnosis in a Coupled Low-Dimensional Framework
We propose a joint dictionary learning framework that couples imaging and genetics data in a low dimensional subspace as guided by clinical diagnosis. We use a graph regularization penalty to simultaneously ca...
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Article
Open AccessNovel genetic loci associated with hippocampal volume
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are foun...
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Article
Novel genetic loci underlying human intracranial volume identified through genome-wide association
In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cogni...
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Article
Common genetic variants influence human subcortical brain structures
Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes ...
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Article
Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia
The purpose of this study was to examine measures of anatomical connectivity between the thalamus and lateral prefrontal cortex (LPFC) in schizophrenia and to assess their functional implications. We measured ...
