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  1. Article

    Open Access

    Metallothionein crypt-restricted immunopositivity indices (MTCRII) correlate with aberrant crypt foci (ACF) in mouse colon

    Metallothionein (MT) crypt-restricted immunopositivity indices (MTCRII) are colonic crypt stem cell mutation markers that may be induced early and in abundance after mutagen treatment. Metallothionein is the e...

    E T Donnelly, H Bardwell, G A Thomas, E D Williams, M Hoper… in British Journal of Cancer (2005)

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  2. Article

    Open Access

    Resveratrol inhibits benzo[a]pyrene–DNA adduct formation in human bronchial epithelial cells

    Resveratrol (trans-3,4′,5-trihydroxystilbene), a phytoalexin present in various plants and foods, has in several in vitro and in vivo studies demonstrated cancer chemopreventive and chemotherapeutic potential. We...

    G Berge, S Øvrebø, I V Botnen, A Hewer, D H Phillips, A Haugen… in British Journal of Cancer (2004)

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  3. No Access

    Article

    Idoxifene is equipotent to tamoxifen in inhibiting mammary carcinogenesis but forms lower levels of hepatic DNA adducts

    Tamoxifen is an effective agent preventing mammary carcinogenesis in rats but causing liver tumours. Idoxifene is a more potent antioestrogen and is effective in patients with advanced breast cancer. We theref...

    P Pace, M Jarman, D Phillips, A Hewer, J Bliss, RC Coombes in British Journal of Cancer (1997)

  4. No Access

    Article

    Aromatic DNA adducts in white blood cells of coke workers

    White blood cell DNA adducts were measured in coke workers, local controls and countryside controls using the 32P-postlabelling technique. The method detected aromatic adducts including those formed by polycyclic...

    K. Hemminki, E. Grzybowska, M. Chorazy… in International Archives of Occupational and… (1990)

  5. No Access

    Article

    Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

    CARCINOGENIC polycyclic hydrocarbons such as the widespread environmental contaminant, benzo(a)pyrene (Fig. 1a), undoubtedly require metabolic activitation. Boyland1 proposed that epoxides, whose formation is cat...

    P. SIMS, P. L. GROVER, A. SWAISLAND, K. PAL, A. HEWER in Nature (1974)