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  1. No Access

    Article

    Primary cultures of prostate cells and their ability to activate carcinogens

    Differences in the incidence of prostate cancer (CaP) amongst different migrant populations point to causative agents of dietary and/or environmental origin. Prostate tissues were obtained following transureth...

    F L Martin, K J Cole, G H Muir, G G Kooiman… in Prostate Cancer and Prostatic Diseases (2002)

  2. No Access

    Chapter

    Polycyclic Aromatic Hydrocarbons: Metabolism, Activation and Tumour Initiation

    Polycyclic aromatic hydrocarbons (PAH) are formed as products of the incomplete pyrolysis of organic materials and are present in considerable quantities in fossil fuel from which they are released by a variet...

    M. Hall, P. L. Grover in Chemical Carcinogenesis and Mutagenesis I (1990)

  3. No Access

    Chapter and Conference Paper

    The Involvement of Bay-Region and Non-Bay-Region Diol-epoxides in the in Vivo Binding of Benz(a)anthrocene Derivatives to DNA

    Progress in the understanding of the metabolic activation of polycyclic aromatic hydrocarbons has resulted from studies in which photon counting spectrophotofluorimetry has been used to examine the hydrocarbon...

    P. Vigny, M. Kindts, C. S. Cooper, P. L. Grover… in Industrial and Environmental Xenobiotics (1981)

  4. No Access

    Article

    Comparison of mutagenesis and malignant transformation by dihydrodiols from benz[a]anthracene and 7,12-dimethylbenz[a]anthracene

    Five dihydrodiols derived from benz[a]anthracene (BA) and 4 dihydrodiols derived from 7,12-dimethylbenz[a]anthracene (DMBA) have been tested, together with the parent hydrocarbons, for their abilities to induc...

    H Marquardt, S Baker, B Tierney, P L Grover, P Sims in British Journal of Cancer (1979)

  5. No Access

    Article

    Biological activities of dihydrodiols derived from two polycyclic hydrocarbons in rodent test systems

    Comparisons have been made between (a) the initiation of tumours in mouse skin, (b) the induction of hyperplasia and the suppression of sebaceous glands in mouse skin and (c) the induction of s.c. tumours in r...

    I Chouroulinkov, A Gentil, B Tierney, P L Grover, P Sims in British Journal of Cancer (1979)

  6. No Access

    Article

    Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene

    Three dihydrodiols that are metabolites of benzo[a]pyrene and benzo[a]-pyrene itself have been tested in a comparative experiment for their activities as initiators of tumours in mouse skin. A single applicati...

    I Chouroulinkov, A Gentil, P L Grover, P Sims in British Journal of Cancer (1976)

  7. No Access

    Article

    The carcinogenicity of polycyclic hydrocarbon epoxides in newborn mice

    Benz(a)anthracene injected subcutaneously during the first 3 days of life caused a dose related increase in the incidence of liver and lung tumours in Swiss mice but over a similar dose range, the K region epo...

    P L Grover, P Sims, B C Mitchley, F J Roe in British Journal of Cancer (1975)

  8. No Access

    Article

    Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

    CARCINOGENIC polycyclic hydrocarbons such as the widespread environmental contaminant, benzo(a)pyrene (Fig. 1a), undoubtedly require metabolic activitation. Boyland1 proposed that epoxides, whose formation is cat...

    P. SIMS, P. L. GROVER, A. SWAISLAND, K. PAL, A. HEWER in Nature (1974)

  9. No Access

    Article

    Hydrocarbon-deoxyribonucleoside products formed by the binding of derivatives of 7-methylbenz(A)anthracene to DNA

    W M Baird, A Dipple, P L Grover, P Sims, P Brookes in British Journal of Cancer (1973)

  10. No Access

    Article

    Variations dependent on Age and Diet in the Metabolism of 7,12-Dimethylbenz[a]-anthracene by Rat Liver Homogenates

    7,12-DIMETHYLBENZ[A]ANTHRACENE (DMBA) causes severe adrenocortical necrosis when administered intragastrically to 50 day old rats1, but it has no effect on the adrenal glands of 25 day old animals2. The activity ...

    P. SIMS, P. L. GROVER in Nature (1967)

  11. No Access

    Article

    Further Experiments on Implantation of Materials into the Urinary Bladder of Mice

    E Boyland, E R Busby, C E Dukes, P L Grover, D Manson in British Journal of Cancer (1964)

  12. No Access

    Article

    A Further Study of Bladder Implantation in the Mouse as a means of Detecting Carcinogenic Activity: Use of Crushed Paraffin Wax or Stearic Acid as the Vehicle

    Georgiana M Bonser, E Boyland, E R Busby, D B Clayson… in British Journal of Cancer (1963)

  13. No Access

    Article

    Carcinogenicity of 2-Naphthylhydroxylamine and 2-Naphthylamine

    E Boyland, C E Dukes, P L Grover in British Journal of Cancer (1963)

  14. No Access

    Article

    The Induction of Renal Tumours by Feeding Lead Acetate to Rats

    E Boyland, C E Dukes, P L Grover, B C V Mitchley in British Journal of Cancer (1962)