34 Result(s)

Article

A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo

Plastic pollution, especially by nanoplastics (NPs), has become an emerging topic due to the widespread existence and accumulation in the environment. The research on bioaccumulation and toxicity mechanism of ...

Narmin Bashirova, David Poppitz, Nils Klüver, Stefan Scholz… in Scientific Reports (2023)

Article

Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome

The leptin signaling pathway plays an important role as a key regulator of glucose homeostasis, metabolism control and systemic inflammatory responses. However, the metabolic effects of leptin on infectious di...

Yi Ding, Mariëlle C. Haks, Susan J. F. van den Eeden, Tom H. M. Ottenhoff… in Metabolomics (2022)

Article

Photo-CIDNP in Solid State

Photo-CIDNP (photo-chemically induced dynamic nuclear polarization) refers to nuclear polarization created by the spin-chemical evolution of spin-correlated radical pairs (SCRPs). This phenomenon occurs in gas...

Jörg Matysik, Yonghong Ding, Yunmi Kim, Patrick Kurle… in Applied Magnetic Resonance (2022)

Article

An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling

Ochratoxin A (OTA) is one of the most widespread mycotoxin contaminants of agricultural crops. Despite being associated with a range of adverse health effects, a comprehensive systems-level mechanistic understand...

Muhamed N. H. Eeza, Narmin Bashirova, Zain Zuberi, Jörg Matysik… in Scientific Reports (2022)

Article

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brain lesions, multifocal white matter alterations, cerebral atrophy, and severe psychomotor impairment. The phenotype is simila...

Matthias Kettwig, Katharina Ternka, Kristin Wendland… in Nature Communications (2021)

Article

Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways

Leptin plays a critical role in the regulation of metabolic homeostasis. However, the molecular mechanism and cross talks between leptin and metabolic pathways leading to metabolic homeostasis across different...

Yi Ding, Mariëlle C. Haks, Gabriel Forn-Cuní, Junling He… in Cell & Bioscience (2021)

Article

Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae

Tuberculosis is a highly infectious and potentially fatal disease accompanied by wasting symptoms, which cause severe metabolic changes in infected people. In this study we have compared the effect of mycobacteri...

Yi Ding, Robert-Jan Raterink, Rubén Marín-Juez, Wouter J. Veneman… in Scientific Reports (2020)

Article

Magnetic Resonance Microscopy at Cellular Resolution and Localised Spectroscopy of Medicago truncatula at 22.3 Tesla

Interactions between plants and the soil’s microbial & fungal flora are crucial for the health of soil ecosystems and food production. Microbe-plant interactions are difficult to investigate in situ due to their ...

Remco van Schadewijk, Julia R. Krug, Defeng Shen… in Scientific Reports (2020)

Article

Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit

Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC) is a rare type of leukodystrophy characterized by astrocyte and myelin vacuolization, epilepsy and early-onset macrocephaly. MLC is caused by mu...

Carla Pérez-Rius, Mónica Folgueira… in Orphanet Journal of Rare Diseases (2019)

Article

Studying hydrogen bonding and dynamics of the acetylate groups of the Special Pair of Rhodobacter sphaeroides WT

Although the cofactors in the bacterial reaction centre of Rhodobacter sphaeroides wild type (WT) are arranged almost symmetrically in two branches, the light-induced electron transfer occurs selectively in one b...

Daniel Gräsing, Katarzyna M. Dziubińska-Kühn, Stefan Zahn, A. Alia… in Scientific Reports (2019)

Article

Photochemically induced dynamic nuclear polarization NMR on photosystem II: donor cofactor observed in entire plant

The solid-state photo-CIDNP (photochemically induced dynamic nuclear polarization) effect allows for increase of signal and sensitivity in magic-angle spinning (MAS) NMR experiments. The effect occurs in photo...

Geertje J. Janssen, Pavlo Bielytskyi, Denis G. Artiukhin… in Scientific Reports (2018)

Article

Metabolic profiling of zebrafish (Danio rerio) embryos by NMR spectroscopy reveals multifaceted toxicity of β-methylamino-L-alanine (BMAA)

β-methylamino-L-alanine (BMAA) has been linked to several interrelated neurodegenerative diseases. Despite considerable research, specific contributions of BMAA toxicity to neurodegenerative diseases remain to...

Upasana Roy, Laura Conklin, Jürgen Schiller, Jörg Matysik… in Scientific Reports (2017)

Article

Field-cycling NMR with high-resolution detection under magic-angle spinning: determination of field-window for nuclear hyperpolarization in a photosynthetic reaction center

Several parameters in NMR depend on the magnetic field strength. Field-cycling NMR is an elegant way to explore the field dependence of these properties. The technique is well developed for solution state and ...

Daniel Gräsing, Pavlo Bielytskyi, Isaac F. Céspedes-Camacho, A. Alia… in Scientific Reports (2017)

Article

An Arabidopsis mutant with high operating efficiency of Photosystem II and low chlorophyll fluorescence

The overall light energy to biomass conversion efficiency of plant photosynthesis is generally regarded as low. Forward genetic screens in Arabidopsis have yielded very few mutants with substantially enhanced ...

Niels van Tol, Martijn Rolloos, Dieuwertje Augustijn, A. Alia… in Scientific Reports (2017)

Article

Removal of pacemaker leads in extracorporeal circulation

E Likaj, A Kacani, S Dumani, D Hasi, A Alia, A Kenga… in Journal of Cardiothoracic Surgery (2013)