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Modulation of VEGFA Signaling During Heart Regeneration in Zebrafish
Over the last decades, myocardial infarction and heart failure have accounted every year for millions of deaths worldwide. After a coronary occlusion, the lack of blood supply to downstream muscle leads to cel...
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Article
Open AccessTuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae
Tuberculosis is a highly infectious and potentially fatal disease accompanied by wasting symptoms, which cause severe metabolic changes in infected people. In this study we have compared the effect of mycobacteri...
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Article
Open AccessInfection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection
The function of Toll-like receptor 2 (TLR2) in host defense against pathogens, especially Mycobacterium tuberculosis (Mtb) is poorly understood. To investigate the role of TLR2 during mycobacterial infection, we ...
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Article
Open AccessImmune responses in cardiac repair and regeneration: a comparative point of view
Immediately after cardiac injury, the immune system plays major roles in repair and regeneration as it becomes involved in a number of processes including damage-associated signaling, inflammation, revasculari...
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Article
Open AccessHHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet,...
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Article
Open AccessHif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
Macrophages are known to interact with endothelial cells during developmental and pathological angiogenesis but the molecular mechanisms modulating these interactions remain unclear. Here, we show a role for t...
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Article
Open AccessCommon and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish
Although the responses to many pathogen associated molecular patterns (PAMPs) in cell cultures and extracted organs are well characterized, there is little known of transcriptome responses to PAMPs in whole or...
