![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Myositis als postakute Folge einer COVID-19-Erkrankung?
Es wird über eine an COVID-19 erkrankte Patientin mit Verdacht auf eine Myositis als Folge einer SARS-CoV-2-Infektion berichtet. Initial führte wenig Information über die Krankengeschichte zur erschwerten hist...
-
Article
Routinemäßige zielgerichtete Hochdurchsatzsequenzierung von lymphoproliferativen Erkrankungen
Im Gegensatz zu anderen Tumorentitäten wie dem Lungenkarzinom, dem Melanom oder gynäkologischen und gastrointestinalen Tumoren ist der routinemäßige Einsatz von Mutationsanalysen mittels Hochdurchsatzsequenzie...
-
Article
Open AccessHigh-throughput sequencing of nodal marginal zone lymphomas identifies recurrent BRAF mutations
Nodal marginal zone lymphoma (NMZL) is a rare small B-cell lymphoma lacking disease-defining phenotype and precise diagnostic markers. To better understand the mutational landscape of NMZL, particularly in com...
-
Article
Ektopien des Thymus und ektope Thymustumoren
Ektopien von Thymusgewebe außerhalb des „Thymus-Kerngebiets“ im vorderen, oberen Mediastinum sind aufgrund der komplexen Embryonalentwicklung des Thymus relativ häufig, wobei berichtete Prävalenzen (1–90 %) st...
-
Article
Concordant bone marrow involvement of diffuse large B-cell lymphoma represents a distinct clinical and biological entity in the era of immunotherapy
In diffuse large B-cell lymphoma (DLBCL), the clinical and biological significance of concordant and discordant bone marrow (BM) involvement have not been well investigated. We evaluated 712 de novo DLBCL patient...
-
Article
Phosphorylated CXCR4 expression has a positive prognostic impact in colorectal cancer
The CXCL12-CXCR4 chemokine axis plays an important role in cell trafficking as well as in tumor progression. In colorectal cancer (CRC), the chemokine receptor CXCR4 has been shown to be an unfavorable prognos...
-
Article
Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma
PRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently inactivated in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) patients. Little is known about its genetic aberrat...
-
Article
Distinct genetic evolution patterns of relapsing diffuse large B-cell lymphoma revealed by genome-wide copy number aberration and targeted sequencing analysis
Recurrences of diffuse large B-cell lymphomas (DLBCL) result in significant morbidity and mortality, but their underlying genetic and biological mechanisms are unclear. Clonal relationship in DLBCL relapses so...
-
Article
Persistierende herdförmige Bindehautläsion
Berichtet wird über eine 26-jährige Patientin, die zur Mitbeurteilung und Durchführung weiterer Diagnostik mit einer seit 4 Monaten bestehenden Bindehautschwellung/Rötung nasal am linken Auge, einhergehend mit...
-
Article
Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium
Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a unique subtype of DLBCL. The impact of rituximab on survival and patterns of treatment failure in PT-DLBCL patient remain controversial. We anal...
-
Article
Numerical impairment of nestin+ bone marrow niches in acute GvHD after allogeneic hematopoietic stem cell transplantation for AML
The nestin+ perivascular bone marrow (BM) stem cell niche (N+SCN) may be involved in GvHD. To investigate whether acute GvHD (aGvHD) reduces the number of N+SCN, we examined patients with AML who had undergone al...
-
Article
Author’s response to “Letter to the editor: unvalidated antibodies and misleading results”
-
Article
Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor
-
Article
Open AccessA role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma
Dysregulated expression of factors that control protein synthesis is associated with poor prognosis of many cancers, but the underlying mechanisms are not well defined. Analysis of the diffuse large B-cell lym...
-
Article
Erratum: Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study
Correction to: Leukemia (2012) 26, 2103–2113; doi:10.1038/leu.2012.83 Since the publication of this article, the authors have identified an omission in their paper, namely that important Supplementary Data was...
-
Article
CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia
The CXCR4 receptor is a major regulator of hematopoietic cell migration. Overexpression of CXCR4 has been associated with poor prognosis in acute myelogenous leukemia (AML). We have previously shown that ligan...
-
Article
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma
Myeloid cell leukemia-1 (MCL1) is an anti-apoptotic member of the BCL2 family that is deregulated in various solid and hematological malignancies. However, its role in the molecular pathogenesis of diffuse lar...
-
Article
GVHD after allogeneic haematopoietic SCT for AML: angiogenesis, vascular endothelial growth factor and VEGF receptor expression in the BM
There is increasing evidence suggesting that both angiogenesis and endothelial injury are involved in GVHD. To study the dynamics of angiogenesis, we examined 26 patients with AML who had undergone allogeneic ...
-
Article
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
Proapoptotic Bcl-2 family members of the Bcl-2 homology (BH)3-only subgroup are critical for the establishment and maintenance of tissue homeostasis and can mediate apoptotic cell death in response to developm...
-
Article
Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo