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Article
Myositis als postakute Folge einer COVID-19-Erkrankung?
Es wird über eine an COVID-19 erkrankte Patientin mit Verdacht auf eine Myositis als Folge einer SARS-CoV-2-Infektion berichtet. Initial führte wenig Information über die Krankengeschichte zur erschwerten hist...
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Article
Open AccessBehandlung retroperitonealer Sarkome in Deutschland
Retroperitoneale Sarkome sind seltene bösartige Tumore. In Deutschland existieren keine zentralisierte Behandlung und keine nationale Behandlungsleitlinie für retroperitoneale Sarkome. Ziel dieser Studie ist d...
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Article
Open AccessVEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors
The inadequate transport of drugs into the tumor tissue caused by its abnormal vasculature is a major obstacle to the treatment of cancer. Anti-vascular endothelial growth factor (anti-VEGF) drugs can cause ph...
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Article
Similar clinical features in follicular lymphomas with and without breaks in the BCL2 locus
Approximately 15% of follicular lymphomas (FLs) lack breaks in the BCL2 locus. The aim of this study was to better define molecular and clinical features of BCL2-breakpoint/t(14;18)-negative FLs. We studied the p...
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Article
Different biological risk factors in young poor-prognosis and elderly patients with diffuse large B-cell lymphoma
Prognostically relevant risk factors in patients with diffuse large B-cell lymphoma (DLBCL) have predominantly been evaluated in elderly populations. We tested whether previously described risk factors are als...
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Article
Open AccessExpression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer
There is evidence that tumour–stroma interactions have a major role in the neoplastic progression of pancreatic ductal adenocarcinoma (PDAC). Tumour budding is thought to reflect the process of epithelial–mese...
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Article
Spontaneous Liver Rupture After Treatment With Drug-Eluting Beads
Spontaneous rupture of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) is a rare and life-threatening complication. Pathophysiologic mechanisms are not yet fully known; it ...
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Chapter
Embryonic Stem Cells: A Novel Tool for the Study of Antiangiogenesis and Tumor-Induced Angiogenesis
Major research initiatives in antiangiogenesis research have been undertaken to control angiogenic diseases such as polyarthritis, psoriasis, endometriosis, and diabetic retinopathy, and inhibition of tumor-in...
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Chapter
Embryonic Stem Cells: A Novel Tool for the Study of Antiangiogenesis and Tumor-Induced Angiogenesis
Major research initiatives in antiangiogenesis research have been undertaken to control angiogenic diseases such as polyarthritis, psoriasis, endometriosis, and diabetic retinopathy, and inhibition of tumor-in...
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Article
Open AccessIncreased doxorubicin uptake and toxicity in multicellular tumour spheroids treated with DC electrical fields
Electrochemotherapy (ECT) is a new approach to the treatment of tumours. In the present study, multicellular prostate tumour spheroids were treated with non-lethal direct current (DC) electrical fields, and up...
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Article
DC electrical field-induced c-fos expression and growth stimulation in multicellular prostate cancer spheroids
The effects of electrical direct current (DC) field pulses on c-fos expression, growth kinetics and vitality patterns of multicellular tumour spheroids (MCSs) were studied. Monitoring the membrane potential of...
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Article
Void Morphology in Polyethylene/Carbon Black Composites
A combination of small angle neutron scattering (SANS) and contrast matching techniques is used to determine the size and quantity of voids incorporated during fabrication of polyethylene/carbon black composit...
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Chapter
Local determination of oxygenation and cell vitality in multicellular spheroids by microelectrodes and photometry
Multicellular spheroids are nearly spherical aggregates of cultured tumor cells. They develop radial proliferation gradients and are used as models to study radiation as well as drug effects for improving ther...
