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  1. No Access

    Article

    Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults

    E C Nelson, A Agrawal, M L Pergadia, M T Lynskey, A A Todorov… in Molecular Psychiatry (2009)

  2. No Access

    Article

    Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

    Alcohol dependence frequently co-occurs with cigarette smoking, another common addictive behavior. Evidence from genetic studies demonstrates that alcohol dependence and smoking cluster in families and have sh...

    J C Wang, R Grucza, C Cruchaga, A L Hinrichs, S Bertelsen… in Molecular Psychiatry (2009)

  3. No Access

    Article

    ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry

    A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low all...

    L J Bierut, A M Goate, N Breslau, E O Johnson, S Bertelsen, L Fox… in Molecular Psychiatry (2012)

  4. No Access

    Article

    A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53

    Several studies have identified genes associated with alcohol-use disorders (AUDs), but the variation in each of these genes explains only a small portion of the genetic vulnerability. The goal of the present ...

    J-C Wang, T Foroud, A L Hinrichs, N X H Le, S Bertelsen, J P Budde… in Molecular Psychiatry (2013)

  5. No Access

    Article

    A novel Alzheimer disease locus located near the gene encoding tau protein

    APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’...

    G Jun, C A Ibrahim-Verbaas, M Vronskaya, J-C Lambert, J Chung… in Molecular Psychiatry (2016)

  6. Article

    Open Access

    Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures

    Age at onset of alcohol dependence (AO-AD) is a defining feature of multiple drinking typologies. AO-AD is heritable and likely shares genetic liability with other aspects of alcohol consumption. We examine wh...

    M Kapoor, Y-L Chou, H J Edenberg, T Foroud, N G Martin… in Translational Psychiatry (2016)

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  7. No Access

    Article

    Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

    The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated mu...

    R C Culverhouse, N L Saccone, A C Horton, Y Ma, K J Anstey… in Molecular Psychiatry (2018)

  8. No Access

    Article

    Genome-wide association study identifies a novel locus for cannabis dependence

    Despite moderate heritability, only one study has identified genome-wide significant loci for cannabis-related phenotypes. We conducted meta-analyses of genome-wide association study data on 2080 cannabis-depe...

    A Agrawal, Y-L Chou, C E Carey, D A A Baranger, B Zhang, R Sherva… in Molecular Psychiatry (2018)

  9. No Access

    Article

    Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability

    Impulsivity, a multifaceted behavioral hallmark of attention-deficit/hyperactivity disorder (ADHD), strongly influences addiction vulnerability and other psychiatric disorders that incur enormous medical and s...

    M L Miller, Y Ren, H Szutorisz, N A Warren, C Tessereau, G Egervari… in Molecular Psychiatry (2018)