91 Result(s)
within
**zhuo Wang
Life Sciences
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Article
Open AccessAmeliorating and refining islet organoids to illuminate treatment and pathogenesis of diabetes mellitus
Diabetes mellitus, a significant global public health challenge, severely impacts human health worldwide. The organoid, an innovative in vitro three-dimensional (3D) culture model, closely mimics tissues or or...
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Effects of different light conditions on morphological, anatomical, photosynthetic and biochemical parameters of Cypripedium macranthos Sw
In this study, the morphological (plant height, leaf length and width, stem diameter and leaf number), anatomical (epidermal cell density and thickness, Stomatal length and width), photosynthetic (net photosyn...
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Article
Open AccessGreenhouse covering cultivation promotes chlorophyll accumulation of tea plant (Camellia sinensis) by activating relevant gene expression and enzyme activity
The tea plant (Camellia sinensis (L.) O. Kuntze) is one of the most economically important woody crops. Plastic greenhouse covering cultivation has been widely used in tea areas of northern China. Chlorophyll is ...
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Open AccessNextDenovo: an efficient error correction and accurate assembly tool for noisy long reads
Long-read sequencing data, particularly those derived from the Oxford Nanopore sequencing platform, tend to exhibit high error rates. Here, we present NextDenovo, an efficient error correction and assembly too...
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Open AccessInsights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases
Autophagy is a dynamic self-renovation biological process that maintains cell homeostasis and is responsible for the quality control of proteins, organelles, and energy metabolism. The E1-like ubiquitin-activa...
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Open AccessGenome-wide characterization and expression of Oryza sativa AP2 transcription factor genes associated with the metabolism of mesotrione
The APETALA2 (AP2) transcription factor (TF) superfamily, one of the largest gene families in plants, plays an essential role in regulating plant growth and their stress responses. However, the role of AP2 in ...
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Article
Open AccessDPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2
Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of castration-resistant prostate cancer resistant to androgen receptor (AR) inhibitors. Our study unveils that AR suppresses the ne...
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Open AccessTranscriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits
Milk production traits are complex traits with vital economic importance in the camel industry. However, the genetic mechanisms regulating milk production traits in camels remain poorly understood. Therefore, ...
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Open AccessTargeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma
Emerging evidence indicates that SOX2 is an oncogene for esophageal squamous cell carcinoma (ESCC). However, direct targeting of SOX2 is not feasible given that this transcription factor plays important roles ...
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Article
Clostridium brassicae sp. nov., A Strictly Anaerobic Bacterium Isolated from High-Salt Industrial Wastewater
An obligately anaerobic, Gram-positive, rod-shaped bacterium (1.8–5.5 μm long, 0.6–0.9 μm wide), designated ZC22-4T, was isolated from a pickle-processing wastewater treatment plant in Zhejiang province, P.R. Chi...
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Open AccessCorrection to: Performance comparison of four types of target enrichment baits for exome DNA sequencing
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Article
Open AccessCLASRP oncogene as a novel target for colorectal cancer
Clk4-associated serine/arginine-rich protein (CLASRP), an alternative splicing regulator, may be involved in the development and progression of cancer by regulating the activity of the CDC-like kinase (Clk) famil...
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Open AccessA frog peptide provides new strategies for the intervention against skin wound healing
Amphibian derived pro-healing peptides as molecular probes might provide a promising strategy for development of drug candidates and elucidation of cellular and molecular mechanisms of skin wound healing. A no...
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Correction to: Geographical, Sex, Age, and Seasonal Differences in Serum Manganese Status Among Chinese Adults with Hypertension
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Geographical, Sex, Age, and Seasonal Differences in Serum Manganese Status Among Chinese Adults with Hypertension
Manganese (Mn) is an essential trace metal element required for optimal human health. However, few studies have assessed the Mn status in hypertensive patients, especially in China. Moreover, factors associate...
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Article
Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy
Rab11a is a novel identified tumorigenic factor involved in different cancers.
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Open AccessDiscovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates
Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease...
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High and Economical Nattokinase Production with Acetoin as a Useful Byproduct from Soybean Milk and Glucose
Nattokinase (NK) is a potent fibrinolytic enzyme with wide pharmaceutical and nutraceutical applications. Safe and high NK-yielding strains are urgently needed. In this study, the best strain NDF was isolated ...
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The Diversity of Vaginal Microbiota Predicts Neoadjuvant Chemotherapy Responsiveness in Locally Advanced Cervical Cancer
The vaginal microbiota is closely related to HPV infection and cervical cancer (CC), but its relationship with platinum-based chemotherapy responsiveness is unknown. The study aimed to investigate the vaginal ...
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Ecological niche complexity of invasive and native cryptic species of the Bemisia tabaci species complex in China
Bemisia tabaci is an important pest affecting agricultural and horticultural crops worldwide and comprises a complex of cryptic species. In China, the introduction of the two invasive cryptic species, Middle East...
