-
Article
Open AccessDUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our study demonstrated that decreased DUSP22 expression ...
-
Article
Open AccessThe implication of serum HLA-G in angiogenesis of multiple myeloma
Despite the advances of therapies, multiple myeloma (MM) remains an incurable hematological cancer that most patients experience relapse. Tumor angiogenesis is strongly correlated with cancer relapse. Human le...
-
Article
Open AccessAn ultra-deep TSV technique enabled by the dual catalysis-based electroless plating of combined barrier and seed layers
Silicon interposers embedded with ultra-deep through-silicon vias (TSVs) are in great demand for the heterogeneous integration and packaging of opto-electronic chiplets and microelectromechanical systems (MEMS...
-
Article
Open AccessEfficacy and safety of intrathecal dexamethasone combined with isoniazid in the treatment of tuberculous meningitis: a meta-analysis
The treatment regimen for tuberculous meningitis (TBM) remains unclear and requires optimization. There are some reports on successful adjunct intrathecal dexamethasone and isoniazid (IDI) treatment strategies...
-
Article
Open AccessAdvanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters
Advanced glycation end product-modified low-density lipoprotein (AGE-LDL) is related to inflammation and the development of atherosclerosis. Additionally, it has been demonstrated that receptor for advanced gl...
-
Article
Open AccessReal-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan
Eight-week glecaprevir/pibrentasvir (GLE/PIB) is indicated for treatment-naïve (TN) patients with chronic hepatitis C (CHC), with or without compensated cirrhosis. Given that the Taiwanese government is commit...
-
Article
To-Former: semantic segmentation of transparent object with edge-enhanced transformer
Transparent objects are widely present in our daily environment. The precise semantic segmentation of transparent objects is crucial for enhancing the perception and comprehension of visual scenes in computer ...
-
Article
Theoretical Predictions and Experimental Confirmations of Phase Selection and Microstructure Evolution Inside Rapidly Solidifying Ti62Ni38 Hyperperitectic Alloy
The phase selection and microstructure evolution inside rapidly solidified Ti62Ni38 alloy have been theoretically predicted by a typical nucleation theory and experimentally confirmed by both the arc melting and ...
-
Article
Distinct roles of excitatory and inhibitory neurons in the medial prefrontal cortex in the expression and reconsolidation of methamphetamine-associated memory in male mice
Methamphetamine, a commonly abused drug, is known for its high relapse rate. The persistence of addictive memories associated with methamphetamine poses a significant challenge in preventing relapse. Memory re...
-
Article
Increased altitudes change sleep status among Chinese population
Sleep is integral to human health. Accumulating evidence has revealed that sleep characteristics could be influenced by altitudes. However, few studies explored what the trajectories of sleep status are along ...
-
Article
Analysis of mutation profiles in extranodal NK/T-cell lymphoma: clinical and prognostic correlations
The molecular pathogenesis of extranodal NK/T-cell lymphoma (NKTCL) remains obscured despite the next-generation sequencing (NGS) studies explored on ever larger cohorts in the last decade. We addressed the hi...
-
Article
A Hydrodynamic Model and Data-Driven Evolutionary Multi-Objective Optimization Algorithm Based Optimal Operation Method for Multi-barrage Flood Control
The flood control operation of river barrages represents a multi-objective optimization problem with conflicting decision objectives, introducing risks into the decision-making process. Most existing optimizat...
-
Article
Open AccessIncreased prevalence but decreased survival of nonviral hepatocellular carcinoma compared to viral hepatocellular carcinoma in recent ten years
Due to the comprehensive hepatitis B virus vaccination program in Taiwan since 1986, the development of antiviral therapy for chronic hepatitis B and chronic hepatitis C infection and covered by National healt...
-
Article
Investigating soil arching evolution in dense sand via fully-instrumented trapdoor tests
A comprehensive analysis of the evolutionary dynamics of soil arches is crucial for accurately predicting soil deformations above sinkholes and assessing stability of underground structures. In this study, a s...
-
Article
Open AccessStylePart: image-based shape part manipulation
Direct part-level manipulation of man-made shapes in an image is desired given its simplicity. However, it is not intuitive given the existing manually created cuboid and cylinder controllers. To tackle this prob...
-
Article
Next-generation sequencing of cerebrospinal fluid for the diagnosis and monitoring of neurocysticercosis
-
Article
Open AccessAn algorithm for simplified hepatitis C virus treatment with non-specialist care based on nation-wide data from Taiwan
Both European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases and the Infectious Diseases Society of America (AASLD-IDSA) guidelines recommend simplified ...
-
Article
A comparative study of macrosegregation evolution kinetics for undercooled Cu60Fe40 immiscible alloy during slow cooling and rapid cooling processes
The macrosegregation evolution kinetics of undercooled Cu60Fe40 immiscible alloy during slow cooling and rapid cooling processes were investigated by laser heating and glass fluxing techniques. The critical under...
-
Article
Open AccessCDKN2A promoter methylation enhances self-renewal of glioblastoma stem cells and confers resistance to carmustine
Glioblastoma, a highly aggressive form of brain cancer, poses significant challenges due to its resistance to therapy and high recurrence rates. This study aimed to investigate the expression and functional im...
-
Article
Neuronal intermediate filament autoimmunity manifesting as ataxia and peripheral neuropathy: a case report and literature review
