-
Article
Open AccessChemo-free treatment of adult patients with Ph-positive acute lymphoblastic leukemia: latest updates from the 2023 ASH annual meeting
The chemo-free concept represents a new direction for managing adult patients with Ph-positive acute lymphoblastic leukemia (Ph + ALL). The tyrosine kinase inhibitors (TKIs), blinatumomab and venetoclax serve ...
-
Article
Investigating soil arching evolution in dense sand via fully-instrumented trapdoor tests
A comprehensive analysis of the evolutionary dynamics of soil arches is crucial for accurately predicting soil deformations above sinkholes and assessing stability of underground structures. In this study, a s...
-
Article
Performance evaluation of underground pipelines subjected to landslide thrust with fiber optic strain sensing nerves
High-accuracy deformation monitoring is crucial for investigating landslide–pipeline interaction problems, in which the fiber optic nerve system (FONS) holds enormous potential. This paper presents a theoretic...
-
Article
Interfacial behavior of soil-embedded fiber optic cables with micro-anchors for distributed strain sensing
Accurate deformation monitoring of geotechnical infrastructures using distributed fiber optic sensing requires a strong interfacial bond between strain sensing cables and surrounding soil. Micro-anchors provi...
-
Article
Assessment of hydro-mechanical properties of biochar-amended soil sourced from two contrasting feedstock
In geo-environmental applications, the potential of biochar has been explored as a suitable cover material of landfill and vegetated slopes. The inherent nature of biochar affects the geo-environmental propert...
-
Article
Failure analyses of open-ended pre-stressed high-strength concrete pile during driving: insights from distributed fiber optic sensing
Open-ended pre-stressed high-strength concrete (PHC) pipe piles are susceptible to progressive distortion and even failure in the vicinity of the pile toe during driving into stiff soil or rock strata. This pa...
-
Article
A Case Study of Performance Comparison Between Vacuum Preloading and Fill Surcharge for Soft Ground Improvement
Vacuum preloading and fill surcharge are two common ground improvement methods, which have been successfully utilized in many soil improvement and land reclamation projects all over the world. Therefore, conti...
-
Article
CAG (cytarabine, aclarubicin and granulocyte colony-stimulating factor) regimen for core binding factor acute myeloid leukaemia with measurable residual disease
Acute myeloid leukaemia (AML) with t (8;21) or inv (16), called core binding factor (CBF) AML, has a favourable prognosis. However, some CBF-AML patients have persistent measurable residual disease (MRD) and a...
-
Article
Open AccessEvaluating mechanism and inconsistencies in hydraulic conductivity of unsaturated soil using newly proposed biochar conductivity factor
In the past few decades, numerous studies have been conducted to promote the use of biochar as a soil amendment and most recently, for compacted geo-engineered soils. In general, the definite trends of biochar...
-
Article
Venetoclax and blinatumomab based chemotherapy-free treatment in a patient with Philadelphia chromosome-negative acute lymphoblastic leukemia
-
Article
Open AccessTargeted treatment of T-cell acute lymphoblastic leukemia: latest updates from the 2022 ASH Annual Meeting
T-cell acute lymphoblastic leukemia (T-ALL) occurs in approximately 25–30% of adult ALL. Currently, treatment approaches for adult patients with T-ALL remain quite limited, with intensive multiagent chemothera...
-
Article
Modeling strip footings on slopes using the material point method
The footing-on-slope system is very complicated since it is governed, in part, by both the bearing capacity and slope stability. The material point method (MPM), which is specifically suitable for large deform...
-
Chapter
Management of Older Patients with Acute Lymphoblastic Leukemia
Although substantial progress is achieved in ALL total therapy in adolescent young adults and adults, marginal improvements in survival over time in older patients present a great challenge. Older patients oft...
-
Chapter
Frontline Management of Elderly Acute Myeloid Leukemia Ineligible for Intensive Treatment
With the improvement of basic science and clinical translation research, the outcome of elderly patients with AML has potentially improved. Novel therapeutic regimens not only improve survival, but also increa...
-
Chapter
Maintenance Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has significantly improved the outcome of patients with acute myeloid leukemia (AML). However, the relapse rate is still high, accounting for abou...
-
Article
Open AccessAn effective and chemotherapy-free strategy of all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia in all risk groups (APL15 trial)
The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has been demonstrated to have comparable effectiveness or better to ATRA and chemotherapy (CHT) in non-high-risk acute promyelocytic...
-
Article
Open AccessOral arsenic and retinoic acid for high-risk acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) has become curable over 95% patients under a complete chemo-free treatment with all-trans retinoic acid (ATRA) and arsenic trioxide in low-risk patients. Minimizing chemother...
-
Article
A real-world study of infectious complications of venetoclax combined with decitabine or azacitidine in adult acute myeloid leukemia
The purpose of this study was to identify the incidence, sites and main pathogens, and risk factors for infectious complications occurring in patients with adult acute myeloid leukemia (AML) during the first c...
-
Article
A field test to investigate spatiotemporal distribution of soil moisture under different cropland covers in the semiarid Loess Plateau of China
In order to simultaneously describe the spatial and temporal variations of soil moisture and the influence of land cover conditions in the semiarid Loess Plateau in Northwestern China, a field test was perform...
-
Article
PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα
Acute promyelocytic leukemia (APL) is a hematological malignancy driven by the oncoprotein PML-RARα, which can be treated with arsenic trioxide (As2O3) or/and all-trans retinoic acid. The protein arginine methylt...
