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Article
Open AccessLeukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis
Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled proliferation of plasma cells in the bone marrow. MM patients with aggressive progression have poor survival, emphasizing the urg...
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Article
Open AccessCell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia
Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML). However, MRD cannot be detected in many patients using current methods. We developed a highly sensitive 5-hydroxymet...
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Article
Open AccessCell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia
Aberrant changes in 5-hydroxymethylcytosine (5hmC) are a unique epigenetic feature in many cancers including acute myeloid leukemia (AML). However, genome-wide analysis of 5hmC in plasma cell-free DNA (cfDNA) ...
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Article
Open AccessMYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. MYCN amplification is found in half of high-risk NB patients; however, no available therapies directly target MYCN. Using...
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Article
Open AccessA novel role of lysophosphatidic acid (LPA) in human myeloma resistance to proteasome inhibitors
Lysophosphatidic acid (LPA) is a naturally occurring phospholipid that regulates cell proliferation, survival, and migration. However, its role on human multiple myeloma (MM) cells is largely unknown. In this ...
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Article
Open AccessDetermining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms
Multiple studies have demonstrated that diffuse large B-cell lymphoma (DLBCL) can be divided into subgroups based on their biology; however, these biological subgroups overlap clinically. Using machine learnin...
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Article
Open AccessMechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus
Quercetin has demonstrated antioxidant, anti-inflammatory, hypoglycemic, and hypolipidemic activities, suggesting therapeutic potential against type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). In ...
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Article
Author Correction: ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions
A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00638-5.
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Article
G6PD deficiency and severity of COVID19 pneumonia and acute respiratory distress syndrome: tip of the iceberg?
The severe pneumonia caused by the human coronavirus (hCoV)-SARS-CoV-2 has inflicted heavy casualties, especially among the elderly and those with co-morbid illnesses irrespective of their age. The high mortal...
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Article
Open AccessXPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53
The XPO1 inhibitor selinexor was recently approved in relapsed/refractory DLBCL patients but only demonstrated modest anti-DLBCL efficacy, prompting us to investigate the prognostic effect of XPO1 in DLBCL pat...
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Article
Peripheral T cell lymphoma, NOS with aberrant αβ and γδ T cell receptor expression in a post-heart transplant patient
Three main patterns of T cell receptor (TCR) expression are identified in peripheral T cell lymphoma (PTCL): TCR-αβ type, TCR-γδ type, and TCR silent type. Cases of PTCL that express both αβ and γδ receptors a...
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Article
Open AccessRecombinant expression, characterization, and quantification in human cancer cell lines of the Anaplastic Large-Cell Lymphoma-characteristic NPM-ALK fusion protein
Systemic anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma most commonly seen in children and young adults. The majority of pediatric ALCLs are associated with the t(2;5)(p23;q35) transloc...
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Article
ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions
Loss of TGF-β tumour suppressive response is a hallmark of human cancers. As a central player in TGF-β signal transduction, SMAD4 (also known as DPC4) is frequently mutated or deleted in gastrointestinal and p...
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Updates in Polycythemia Vera
Polycythemia vera (PV) is a chronic myeloproliferative neoplasm (MPN) characterized by erythrocytosis and clonal Janus kinase 2 (JAK2) V617F or JAK2 exon 12 mutations. The 2016 World Health Organization update ha...
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Article
Open AccessCellular function reinstitution of offspring red blood cells cloned from the sickle cell disease patient blood post CRISPR genome editing
Sickle cell disease (SCD) is a disorder of red blood cells (RBCs) expressing abnormal hemoglobin-S (HbS) due to genetic inheritance of homologous HbS gene. However, people with the sickle cell trait (SCT) carr...
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Article
Overt leukemic phase: an unusual presentation of angioimmunoblastic lymphoma
Peripheral blood dissemination has been described in various types of B- and T-cell non-Hodgkin lymphomas. The likelihood of leukemic dissemination differs according to the type of lymphoma. In some cases, a l...
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Article
Open AccessAutomatic B cell lymphoma detection using flow cytometry data
Flow cytometry has been widely used for the diagnosis of various hematopoietic diseases. Although there have been advances in the number of biomarkers that can be analyzed simultaneously and technologies that ...
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Article
Open AccessMultiplexed volumetric bar-chart chip for point-of-care diagnostics
Microfluidics have become an enabling technology for point-of-care and personalized diagnostics. Desirable capabilities of microfluidics-based diagnostic devices include simplicity, portability, low cost and t...
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Article
Epstein–Barr virus-related lymphoproliferative disorder induced by equine anti-thymocyte globulin therapy
Post-transplant lymphoproliferative disorder (PTLD) is generally caused by an uncontrolled B-cell proliferation induced by Epstein-Barr virus (EBV) in the setting of impaired EBV-specific T-cell immunity. PTLD...
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Article
Open AccessA nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma
Many in vitro studies have demonstrated that silencing of cancerous genes by siRNAs is a potential therapeutic approach for blocking tumor growth. However, siRNAs are not cell type-selective, cannot specifically ...
